Teicoplanin concentrations in serum, pericardium, pericardial fluid and thoracic wall fat in patients undergoing cardio-pulmonary bypass surgery.
Teicoplanin concentrations in serum, pericardium, pericardial fluid and thoracic wall fat in patients undergoing cardio-pulmonary bypass surgery.
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接受体外循环手术的患者血清、心包、心包液和胸壁脂肪中替考拉宁的浓度。
DOI：
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发表时间：
1997
影响因子：
5.2
通讯作者：
R. Padrini
中科院分区：
文献类型：
--
作者：
P. Miglioli;F. Merlo;A. Fabbri;R. Padrini
在接受体外循环（CPB）的患者单次静脉注射后，测量了血清、心包、心包液和胸壁脂肪中替考拉宁的浓度。 12毫克/公斤剂量。 CPB 开始后 5 分钟，替考拉宁血清浓度平均下降 35%（95% 置信区间 (CI)：28-42%），并且在随后的 60 分钟内仍显着低于预期值。主动脉松开后，药物浓度反弹，但在接下来的 60 分钟内仍显着低于预期值。 CPB 前，替考拉宁在心包和胸壁脂肪中的渗透率分别为 0.44 (95% CI: 0.23-0.65) 和 0.05 (95% CI: 0.03-0.7)，并在 CPB 结束时增加至 0.90 (95% CI: 0.55-1.25) 和 0.17 (95% CI: 0.05-0.29), 分别。大多数葡萄球菌菌株的 MIC 是在心包体外循环过程中获得的，但在胸壁脂肪中却没有。然而，由于葡萄球菌感染涉及间质空间，因此渗透到脂肪细胞对于抗菌预防来说可能并不重要。在这方面，值得注意的是，心包液中的药物浓度（应反映间质浓度）高于大多数葡萄球菌菌株的 MIC。尽管在我们有限的患者系列中没有观察到感染并发症，但需要更大规模的临床试验来评估所采用的剂量方案是否能有效预防 CPB 手术后感染。
The concentrations of teicoplanin in serum, pericardium, pericardial fluid and thoracic wall fat were measured in patients undergoing cardio-pulmonary bypass (CPB) after the administration of a single i.v. 12 mg/kg dose. Five minutes after the start of CPB, teicoplanin serum concentrations decreased by, on average, 35% (95% confidence interval (CI): 28-42%) and remained significantly lower than the expected values over the subsequent 60 min period. After aortic unclamping drug concentrations rebounded but remained significantly lower than the expected values in the next 60 min. Immediately before CPB, penetration of teicoplanin in pericardium and thoracic wall fat was 0.44 (95% CI: 0.23-0.65) and 0.05 (95% CI: 0.03-0.7), respectively, and increased at the end of CPB to 0.90 (95% CI: 0.55-1.25) and 0.17 (95% CI: 0.05-0.29), respectively. MICs for most staphylococcal strains were attained during CPB procedure in pericardium but not in thoracic wall fat. However, since staphylococcal infections involve the interstitial space it is likely that penetration into fat cells is not important for antimicrobial prophylaxis. In this respect, it is worth noting that drug concentration in pericardial fluid, which should reflect the interstitial concentration, was higher than the MIC for most staphylococcal strains. Although no infective complications were observed in our limited series of patients, larger clinical trials are needed to assess whether the dose regimen employed is effective in preventing post-CPB surgery infections.
耐甲氧西林金黄色葡萄球菌引起的医院感染的流行病学。
影响因子：
39.2
作者：
Thompson,RL;Cabezudo,I;Wenzel,RP
通讯作者：
Wenzel,RP