Anti-atherogenic property of ferulic acid in apolipoprotein E-deficient mice fed Western diet: Comparison with clofibrate
Anti-atherogenic property of ferulic acid in apolipoprotein E-deficient mice fed Western diet: Comparison with clofibrate
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DOI：
10.1016/j.fct.2010.05.063
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发表时间：
2010-08-01
影响因子：
4.3
通讯作者：
Choi, M. S.
中科院分区：
文献类型：
--
作者：
Kwon, E. Y.;Do, G. M.;Choi, M. S.
观察了阿魏酸(0.02%，w/w)和氯贝特(0.02%，w/w)对喂饲西方饮食的载脂蛋白E缺陷(apo E-/-)小鼠的抗衰老作用。阿魏酸和氯贝特组大鼠血浆总胆固醇(Total-C)、载脂蛋白B(Apo B)浓度和附睾脂组织重量均显著低于对照组。各组载脂蛋白B/载脂蛋白A-I的比值也明显低于对照组。肝脏ACAT和HMG-CoA还原酶活性仅阿魏酸组和氯贝特组显著低于对照组。对照组出现主动脉脂肪斑块的小鼠数量为8/10，而阿魏酸组或氯贝特组为0/10。阿魏酸组大鼠肝细胞和红细胞中超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和对氧磷酶活性明显高于对照组。相反，只有阿魏酸组的肝脏TBARS水平显著低于阿魏酸组。这些结果为阿魏酸在喂养西方饮食的载脂蛋白E-/-小鼠中的抗动脉粥样硬化特性提供了新的见解。(C)2010爱思唯尔有限公司。保留所有权利。
Anti-athereigenic effect of ferulic acid (0.02%, w/w) was investigated in comparison with the clofibrate (0.02%, w/w) in apolipoprotein E-deficient (apo E-/-) mice fed Western diet. Concentrations of total cholesterol (total-C), apolipoprotein B (apo B) in the plasma and epididymal adipose tissue weight were significantly lower in the ferulic acid and clofibrate supplemented groups compared to the control group. The ratio of apo B to apo A-I was also significantly lower in those groups than in the control group. Activities of hepatic ACAT and HMG-CoA reductase were only significantly lower in the ferulic acid and clofibrate groups, respectively than in the control group. The numbers of mice that exhibited aortic fatty plaque were 8/10 in control groups vs. 0/10 in the ferulic acid or clofibrate group. The activities of anti-oxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and paraoxonase) in the hepatocyte and erythrocyte were significantly higher in the ferulic acid group than in the control group. In contrast, hepatic TBARS level was only markedly lower in the ferulic acid group. These results provide a new insight into the anti-atherogenic property of ferulic acid in the apo E-/- mice fed a Western diet. (C) 2010 Elsevier Ltd. All rights reserved.