The Specific Roles of JAK/STAT Signaling Pathway in Sepsis
The Specific Roles of JAK/STAT Signaling Pathway in Sepsis
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JAK/STAT信号通路在脓毒症中的具体作用
DOI：
10.1007/s10753-015-0135-z
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发表时间：
2015-08-01
期刊：
影响因子：
5.1
通讯作者：
Zhang, Sen
中科院分区：
文献类型：
--
作者：
Cai, Bin;Cai, Jian-ping;Zhang, Sen
Janus激酶-信号转导和转录激活因子（JAK/STAT）通路是脓毒症中许多关键细胞因子信号转导的主要信号通路。细胞因子与相应受体的结合可以激活相关的JAK激酶，选择性地磷酸化STATs。激活的STATs随后转运到细胞核，在靶基因的转录中发挥关键作用。在过去的几年中，在了解JAK/STAT通路在脓毒症中的作用方面取得了重大进展。本文综述了JAK/STAT信号通路的现状，阐述了JAK/STAT信号通路在脓毒症中的具体作用，并对JAK/STAT信号通路在脓毒症中的进一步研究提出了展望。在PubMed数据库中搜索jak和STATs在败血症中的研究。研究表明，多种细胞因子可通过JAK/STAT信号通路发挥其生物学作用。JAK/STAT通路与脓毒症中多种细胞因子和炎症介质的释放有关，参与免疫反应的调节。此外，在脓毒症模型中，JAK/STAT通路已被证明参与器官损伤和其他功能障碍。
The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is a principal signaling pathway for the signal transduction of many pivotal cytokines involved in sepsis. Binding of cytokines to corresponding receptors can activate associated JAK kinases, which selectively phosphorylate STATs. Activated STATs then translocate to the nucleus and play a critical role in the transcription of target genes. During the past several years, significant progress has been made in the understanding of the roles of JAK/STAT pathway in sepsis. The aims of this review are to describe the present knowledge about JAK/STAT signaling pathway, describe the specific roles of JAK/STAT pathway in sepsis, and put forward the prospect for future studies of JAK/STAT signaling pathway in sepsis. A PubMed database search was performed for studies of JAKs and STATs in sepsis. It has been shown that a variety of cytokines can exert their biological effects via the JAK/STAT signaling pathway. JAK/STAT pathway has been shown related to the release of various cytokines and inflammatory mediators and involved in the regulation of immune response in sepsis. Moreover, JAK/STAT pathway has been shown involved in organ damage and other dysfunctions in sepsis models.