METASTATIC TUMOR - THE COMPLEMENTARY ROLE OF THE MARROW ASPIRATE AND BIOPSY
METASTATIC TUMOR - THE COMPLEMENTARY ROLE OF THE MARROW ASPIRATE AND BIOPSY
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DOI：
10.1097/00000441-199110000-00003
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发表时间：
1991-10-01
影响因子：
3.1
通讯作者：
GOLDBERG, SN
中科院分区：
文献类型：
--
作者：
ATAC, B;LAWRENCE, C;GOLDBERG, SN
为了确定骨髓穿刺或活检是否在检测骨髓非血液学转移中更敏感，对1975年1月至1986年1月1日在一家800张床位的市级医院获得的所有1569例连续配对活检和穿刺样本进行了回顾。每对至少检查8个抽吸载玻片和10个活检横截面。在39个样本中，活检和抽吸物均确定了转移性肿瘤。没有活检包含在抽吸物上未观察到的肿瘤。然而，5个抽吸载玻片含有在活检中未识别的转移性恶性肿瘤。血液学家或肿瘤学家在1000倍放大率下观察单层中的单个细胞具有识别非常小的肿瘤细胞簇的优势。这占了活检呈阴性的五个阳性抽吸样本中的三个。另外两个阳性抽吸物载玻片各自仅在八个载玻片中的一个载玻片上含有肿瘤。我们的研究结果表明，当仔细审查时，抽吸物至少与骨髓活检一样敏感，以识别转移性肿瘤。我们的研究结果表明，骨髓穿刺和活检是有用的和互补的检查，以确定转移性恶性肿瘤。
To determine whether bone marrow aspiration or biopsy is more sensitive in the detection of nonhematologic metastatic involvement of marrow, all 1569 consecutive paired biopsy and aspirate samples obtained between January 1975 and January 1, 1986 in an 800 bed municipal hospital were reviewed. At least eight aspirate slides and 10 biopsy cross sections were examined for each pair. In 39 samples, both biopsy and aspirate identified metastatic tumor. No biopsies contained tumor that was not also seen on the aspirate. However, five aspirate slides contained metastatic malignancies not identified on biopsy. The hematologist or oncologist viewing individual cells in a monolayer at 1000 x magnification has the advantage of identifying very small clusters of tumor cells. That accounted for three of the five positive aspirate samples in which the biopsies were negative. The other two positive aspirate slides each contained tumor on only one of eight slides. The results of our study indicate that when carefully reviewed, the aspirate is at least as sensitive as the marrow biopsy for identifying metastatic tumor. Our results indicate that marrow aspirates and biopsies are useful and complementary examinations for identifying metastic malignancy.