Whole genome analysis of infectious bovine keratoconjunctivitis in Angus cattle using Bayesian threshold models.
Whole genome analysis of infectious bovine keratoconjunctivitis in Angus cattle using Bayesian threshold models.
复制标题
DOI：
10.1186/1753-6561-5-s4-s22
复制
发表时间：
2011-06-03
期刊：
影响因子：
--
通讯作者：
Reecy, James M
中科院分区：
文献类型：
--
作者：
Kizilkaya, Kadir;Tait, Richard G;Reecy, James M
牛传染性角膜结膜炎（IBK），也称为红眼病，其特征是角膜受损，是肉牛中一种经济上重要的、遗传性低的分类疾病性状。在858头安格斯牛断奶时收集眼损伤评分。从牛SNP 50 Infinium-beadchips获得每只动物的SNP基因型。使用贝叶斯C确定所有SNP与IBK表型的同时关联，贝叶斯C将SNP效应视为随机的，对于对IBK评分没有影响的SNP的假定分数（pi=0.999）具有等方差。贝叶斯-C阈值模型被用来估计SNP的影响，IBK分为两个，三个或九个有序的类别。在整个基因组的局部区域估计的遗传方差的大小表明，在最具信息性的区域内的SNP占IBK的遗传方差的大部分，并指出一定程度的关联IBK。在这些区域中存在许多候选基因，其可能包括与牛中的细菌性疾病相关的基因或基因组。
Infectious bovine keratoconjunctivitis (IBK), also known as pinkeye, is characterized by damage to the cornea and is an economically important, lowly heritable, categorical disease trait in beef cattle. Scores of eye damage were collected at weaning on 858 Angus cattle. SNP genotypes for each animal were obtained from BovineSNP50 Infinium-beadchips. Simultaneous associations of all SNP with IBK phenotype were determined using Bayes-C that treats SNP effects as random with equal variance for an assumed fraction (pi=0.999) of SNP having no effect on IBK scores. Bayes-C threshold models were used to estimate SNP effects by classifying IBK into two, three or nine ordered categories. Magnitudes of genetic variances estimated in localized regions across the genome indicated that SNP within the most informative regions accounted for much of the genetic variance of IBK and pointed out some degree of association to IBK. There are many candidate genes in these regions which could include a gene or group of genes associated with bacterial disease in cattle.