Effect of small doses of syngeneic bone marrow on the 30- and 90-day LD50 of X-irradiated mice.
Effect of small doses of syngeneic bone marrow on the 30- and 90-day LD50 of X-irradiated mice.
复制标题
小剂量同基因骨髓对 X 射线照射小鼠 30 天和 90 天 LD50 的影响。
DOI：
10.2307/3572985
复制
发表时间：
1969
影响因子：
3.4
通讯作者：
L. Smith
中科院分区：
文献类型：
--
作者：
D. Doherty;L. Smith
研究了非常小剂量的同基因骨髓细胞对 X 照射雌性 (C57BL/Cum ♀ × C3H/Anf ♂) F1 小鼠 30 天和 90 天生存的影响，主要在 ${\rm LD}_{10}-{\rm LD}_{100}$ 范围内。少至 0.01× 106 个细胞即可提高暴露于 ${\rm LD}_{100}$ 或更低的小鼠的存活率，并且与等于或高于 ${\rm LD}_{100}$ 的暴露相比，在中等致死暴露下获得良好的存活需要更小的细胞剂量。这些数据与之前的结果一起表明 ${\rm LD}_{50(30)}$ 对同基因骨髓细胞剂量的三相反应。 ${\rm LD}_{50(90)}$ 和 ${\rm LD}_{50(30)}$ 值基本相同，但暴露于 1100、1150 和 1200 R 的小鼠除外。在这些组中，90 天的存活率约为 30 天时的一半。研究还发现，接受骨髓治疗的小鼠的生存曲线斜率约为...的二分之一。
The effects of very small doses of syngeneic bone marrow cells on 30- and 90-day survival of x-irradiated female (C57BL/Cum ♀ × C3H/Anf ♂) F1 mice were studied, principally in the ${\rm LD}_{10}-{\rm LD}_{100}$ range. As few as 0.01× 106 cells improved survival of mice exposed to an ${\rm LD}_{100}$ or less, and a smaller cell dose was required to obtain good survival at mid-lethal exposures than at or above the ${\rm LD}_{100}$ . The data, together with previous results, indicate a triphasic response of the ${\rm LD}_{50(30)}$ to the dose of syngeneic marrow cells. The ${\rm LD}_{50(90)}$ and ${\rm LD}_{50(30)}$ values are essentially the same, except for mice exposed to 1100, 1150, and 1200 R. In these groups 90-day survival percentages were about one-half those scored at 30 days. It was also found that slopes of survival curves for mice treated with marrow were about one-half tho...