Formation and destruction of primary thrombi under the influence of blood flow and von Willebrand factor analyzed by a discrete element method.
Formation and destruction of primary thrombi under the influence of blood flow and von Willebrand factor analyzed by a discrete element method.
复制标题
采用离散元法分析血流和冯维勒布兰德因子影响下原发血栓的形成和破坏。
作者：
Hisako Miyazaki;Takami Yamaguchi
使用称为离散元法 (DEM) 的计算力学方法来模拟血栓形成和溶栓过程，以模拟血流、血小板、血管壁和血管性血友病因子 (vWf) 之间的机械相互作用。 DEM 中包含 vWf 和复杂的血流场是本研究中使用的新进展。如果仅考虑轴向流体力，即使激活 vWf 来模拟内皮损伤，模拟中也不会形成原发性血栓。当径向流体力被认为包括红细胞的排斥效应时，建模的血小板在存在 vWf 的病变处形成原发性血栓。这表明vWf的激活不足以促进原发性血栓的形成；还需要一个复杂的流场，以促进血小板向壁的运输。
Thrombogenesis and thrombolysis processes were simulated using a computational mechanics method called the discrete element method (DEM) to model the mechanical interactions between blood flow, platelets, the vessel wall, and von Willebrand factor (vWf). The inclusion of vWf and a complex blood flow field in the DEM are new developments used in this study. A primary thrombus did not form in the simulations if only the axial fluid force was considered, even when vWf was activated to simulate an endothelial injury. When the radial fluid force was considered to include the exclusion effect of erythrocytes, the modeled platelets formed primary thrombi at lesions where vWf was present. This suggests that activation of vWf is not sufficient to promote the formation of primary thrombi; a complex flow field that facilitates the transport of platelets towards the wall is also required.