Long-term oxytocin administration enhances the experience of attachment
Long-term oxytocin administration enhances the experience of attachment
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DOI：
10.1016/j.psyneuen.2017.01.010
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发表时间：
2017-04-01
影响因子：
3.7
通讯作者：
Alaerts, Kaat
中科院分区：
文献类型：
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作者：
Bernaerts, Sylvie;Prinsen, Jellina;Alaerts, Kaat
众所周知，神经肽“催产素”(OT) 通过促进亲社会态度和人际联系，在各种复杂的社会行为中发挥着关键作用。先前的研究表明，单剂量的外源性 OT 会影响信任和依恋不安全感。在本研究中，我们采用双盲受试者间随机安慰剂对照设计，探讨了两周每日 OT 给药对状态和特质依恋测量的影响。使用国家成人依恋量表和父母和同伴依恋量表，对 40 名健康年轻成年男性在每日鼻内 OT (24 IU) 或安慰剂前后两周的状态和特质依恋进行了评估。情绪、社会反应能力和生活质量也作为次要结果指标进行评估。据报道，经过两周的加班治疗后，回避依恋的情况有所减少，对同伴的依恋有所增加。此外，治疗引起的变化对于对同龄人的安全依恋较差的参与者来说最为明显。表明基线的正常方差调节了治疗反应。 OT 治疗还与情绪变化相关，表明 OT 组的紧张感和（暂时）愤怒感有所减少，而安慰剂组则没有。此外，在为期两周的试验结束时，两个治疗组（OT、安慰剂）均报告社交反应能力和生活质量有所提高，但就“社交动机”报告而言，效果仅针对 OT 治疗。总之，在多剂量 OT 治疗后观察到的依恋状态和特质维度的改善提供了进一步的证据，支持 OT 在促进依恋体验方面的关键作用。 (C) 2017 Elsevier Ltd. 保留所有权利。
The neuropeptide 'oxytocin' (OT) is known to play a pivotal role in a variety of complex social behaviors by promoting a prosocial attitude and interpersonal bonding. Previous studies showed that a single dose of exogenously administered OT can affect trust and feelings of attachment insecurity. With the present study, we explored the effects of two weeks of daily OT administration on measures of state and trait attachment using a double-blind between-subjects randomized placebo-controlled design. In 40 healthy young adult men state and trait attachment were assessed before and after two weeks of daily intranasal OT (24 IU) or placebo using the State Adult Attachment Scale and the Inventory of Parent and Peer Attachment. Mood, social responsiveness and quality of life were additionally assessed as secondary outcome measures. Reductions in attachment avoidance and increases in reports of attachment toward peers were reported after two weeks of OT treatment. Further, treatment-induced changes were most pronounced for participants with less secure attachment towards their peers. indicating that normal variance at baseline modulated treatment response. OT treatment was additionally associated with changes in mood, indicating decreases in feelings of tension and (tentatively) anger in the OT group, not in the placebo group. Further, at the end of the two-week trial, both treatment groups (OT, placebo) reported to experience an increase in social responsiveness and quality of life, but the effects were only specific to the OT-treatment in terms of reports on 'social motivation'. In summary, the observed improvements on state and trait dimensions of attachment after a multiple-dose treatment with OT provide further evidence in support of a pivotal role of OT in promoting the experience of attachment. (C) 2017 Elsevier Ltd. All rights reserved.