ANTIGENIC VARIATION AND RESISTANCE TO NEUTRALIZATION IN POLIOVIRUS TYPE-1
ANTIGENIC VARIATION AND RESISTANCE TO NEUTRALIZATION IN POLIOVIRUS TYPE-1
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DOI：
10.1126/science.2412292
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
WIMMER, E
中科院分区：
文献类型：
--
作者：
DIAMOND, DC;JAMESON, BA;WIMMER, E
1 型脊髓灰质炎病毒 (Mahoney) 变异体已根据其对单克隆抗体中和的抵抗力而被鉴定出突变。这些变体的表型是根据抗体结合来定义的；表达的或能够用于中和的表位模式是复杂的。单个氨基酸的变化可能对脊髓灰质炎病毒和类似病毒体的抗原结构产生遥远的（就线性序列而言）和普遍的影响。
Mutations have been identified in variants of poliovirus, type 1 (Mahoney) on the basis of their resistance to neutralization by individual monoclonal antibodies. The phenotypes of these variants were defined in terms of antibody binding; the pattern of epitopes expressed or able to be exploited for neutralization were complex. Single amino acid changes can have distant (in terms of linear sequence) and generalized effects on the antigenic structure of poliovirus and similarly constituted virions.