mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells

mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells
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DOI:
10.1016/j.bbagen.2008.02.006
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发表时间:
2008-06-01
影响因子:
3
通讯作者:
Ghafourifar, Pedram
Ghafourifar, Pedram
中科院分区:
生物学3区
文献类型:
--
作者:
Parihar, Mordhwaj S.;Parihar, Arti;Ghafourifar, Pedram

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mAtNOS1 is a novel gene recently reported in mammalian cells with functions that are not fully understood. The present study generated human neuroblastoma SHSY cells over- and underexpressing mAtNOS1 and shows that mAtNOS1 is involved in regulating mitochondrial nitric oxide, mitochondrial transmembrane potential, protein tyrosine nitration, cytochrome c release, and apoptosis of those cells. (c) 2008 Elsevier B.V. All rights reserved.