Elastic moduli of thyroid tissues under compression
Elastic moduli of thyroid tissues under compression
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DOI：
10.1177/016173460502700204
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发表时间：
2005-04-01
影响因子：
2.3
通讯作者：
Togashi, K
中科院分区：
文献类型：
--
作者：
Lyshchik, A;Higashi, T;Togashi, K
本研究的目的是评估甲状腺组织在单轴压缩下的弹性模量，并建立准确解释甲状腺弹性图的生物力学基础。共67份甲状腺样本（正常甲状腺组织24例，慢性甲状腺炎甲状腺组织2例，腺瘤性甲状腺肿病变12例，滤泡性腺瘤7例，19份乳头状腺癌（PAC）样本和3份滤泡腺癌（FAC）样本）从36名接受甲状腺手术的患者中获得的材料在手术切除后3小时内以5%的预压缩应变进行生物力学测试，10%和20%，施加的应变为样品高度的1%、2%、5%和10%。结果表明，甲状腺良性病变组织在所有预压缩水平下的弹性模量平均值均显著高于正常甲状腺组织在相同载荷下的弹性模量平均值（p < 0.01）。在低预压缩（5%）和压缩（1-2%）水平下，良性甲状腺结节样品比正常甲状腺组织硬1.7倍。在高预压缩（20%）和压缩（10%）水平下，这一差异增加到2.4倍。在相同载荷下，PAC样品的刚度显著高于正常甲状腺组织和良性甲状腺肿瘤（p < 0.01）。在低预压（5%）和压缩（1-2%）水平下，PAC样品比正常甲状腺组织硬5.0倍。在高预压缩（20%）和压缩（10%）水平下，这一差异增加到17.7倍。相比之下，FAC样品比PAC软得多（p < 0.05），硬度与正常甲状腺组织相当。正常甲状腺组织和甲状腺肿瘤之间硬度的显著差异可能为准确解释甲状腺弹性图提供有用的信息。
The aim of this study was to evaluate the elastic moduli of thyroid tissues under uniaxial compression and to establish the biomechanical fundamentals for accurate interpretation of thyroid elastograms. A total of 67 thyroid samples (24 samples of normal thyroid tissue, 2 samples of thyroid tissue with chronic thyroiditis, 12 samples of adenomatous goiter lesions and 7 samples of follicular adenoma, 19 samples of papillary adenocarcinoma (PAC) and 3 samples of follicular adenocarcinoma (FAC)) obtained from 36 patients who had received thyroid surgery were subjected to biomechanical testing within three hours after surgical resection at precompression strains of 5%, 10% and 20% and applied strains of 1% 2% 5% and 10% of sample height. As a result, the mean values of elastic moduli for benign thyroid lesions at all examined precompression levels were significantly higher than those for normal thyroid tissue measured at the same load (p < 0.01). At low precompression (5%) and compression (1-2%) levels, benign thyroid nodule samples were 1.7 times harder than normal thyroid tissue. At high precompression (20%) and compression (10%) levels, this difference increased to 2.4 times. Stiffness of PAC samples was significantly higher than those for normal thyroid tissue and benign thyroid tumors measured at the same load (p < 0.01). At low precompression (5%) and compression (1-2%) levels, PAC samples were 5.0 times harder than normal thyroid tissue. At high precompression (20%) and compression (10%) levels, this difference increased to 17.7 times. In contrast, samples of FAC were much softer than PAC (p < 0.05) and were comparable in stiffness to normal thyroid tissues. The significant differences in the stiffness between normal thyroid tissue and thyroid tumors may provide useful information for accurate interpretation of thyroid elastograms.