Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase.
Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase.
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DOI：
10.3389/fmolb.2021.727863
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发表时间：
2021
影响因子：
5
通讯作者：
Song J
中科院分区：
文献类型：
--
作者：
Ballard DJ;Peng HY;Das JK;Kumar A;Wang L;Ren Y;Xiong X;Ren X;Yang JM;Song J
真核延伸因子 - 2激酶（eEF2K）作为蛋白质合成、翻译和细胞生长的负调控因子。作为α - 激酶家族中结构独特的成员，eEF2K在应激条件下对细胞存活至关重要，因为它有助于细胞活力和增殖。作为蛋白质翻译全局速率的调节剂，eEF2K在激活时抑制eEF2（真核延伸因子2）并降低翻译延伸。eEF2K受多种机制调控，包括通过残基磷酸化和自身磷酸化。具体而言，这种蛋白激酶通过mTOR信号通路对多个位点的磷酸化而下调，并通过AMPK途径上调。eEF2K在许多生物系统中发挥重要作用，包括神经学、心脏病学、肌肉学和免疫学。本综述进一步深入探讨了eEF2K目前的作用及其作为药物开发治疗靶点的潜力。
Eukaryotic Elongation Factor-2 Kinase (eEF2K) acts as a negative regulator of protein synthesis, translation, and cell growth. As a structurally unique member of the alpha-kinase family, eEF2K is essential to cell survival under stressful conditions, as it contributes to both cell viability and proliferation. Known as the modulator of the global rate of protein translation, eEF2K inhibits eEF2 (eukaryotic Elongation Factor 2) and decreases translation elongation when active. eEF2K is regulated by various mechanisms, including phosphorylation through residues and autophosphorylation. Specifically, this protein kinase is downregulated through the phosphorylation of multiple sites via mTOR signaling and upregulated via the AMPK pathway. eEF2K plays important roles in numerous biological systems, including neurology, cardiology, myology, and immunology. This review provides further insights into the current roles of eEF2K and its potential to be explored as a therapeutic target for drug development.