CHOLINERGIC MODULATION OF FREQUENCY RECEPTIVE-FIELDS IN AUDITORY-CORTEX .2. FREQUENCY-SPECIFIC EFFECTS OF ANTICHOLINESTERASES PROVIDE EVIDENCE FOR A MODULATORY ACTION OF ENDOGENOUS ACH
CHOLINERGIC MODULATION OF FREQUENCY RECEPTIVE-FIELDS IN AUDITORY-CORTEX .2. FREQUENCY-SPECIFIC EFFECTS OF ANTICHOLINESTERASES PROVIDE EVIDENCE FOR A MODULATORY ACTION OF ENDOGENOUS ACH
复制标题
DOI：
10.1002/syn.890040106
复制
发表时间：
1989-01-01
期刊：
影响因子：
2.3
通讯作者：
WEINBERGER, NM
中科院分区：
文献类型：
--
作者：
ASHE, JH;MCKENNA, TM;WEINBERGER, NM
外源施用的毒蕈碱激动剂例如乙酰胆碱（ACh）和乙酰-β-乙酰甲胆碱（MCh）以频率特异性而非全局方式改变未麻醉动物的听觉皮层中的频率感受野。本研究试图通过使用抗胆碱酯酶剂硫酸艾司氯胺酮和梭曼（0- 1，2，2-三甲基丙基甲基膦酰氟），以促进内源性乙酰胆碱的影响，这些发现与内源性乙酰胆碱的行动。通过在应用ACh、MCh、毒扁豆碱或梭曼之前、期间和之后呈现不同等强度音调的序列来确定频率感受野（FRF）;还在应用ACh或MCh之间应用胆碱酯酶阻滞剂。抑制剂产生的主要作用与激动剂相似。主要影响是频率特异性的变化。此外，艾司氯胺酮和梭曼，类似ACh和MCh，产生的最佳频率（BF）的FRF主要是由于协调抑郁症的反应BF和相邻的，非BF的反应增加的移位。结果表明，外源性和内源性乙酰胆碱，通过毒蕈碱受体的作用，可以显着影响皮层神经元的生理功能，从而其处理的感觉信息。
Exogenously applied muscarinic agonists.sbd.for example, acetylcholine (ACh) and acetyl-beta-methacholine (MCh).sbd.modify frequency receptive fields in auditory cortex of unanesthetized animals in a frequency-specific rather than global manner. The present study sought to relate these findings to endogenous actions of ACh by using the anticholinesterase agents eserine sulphate and soman (0-1,2,2-trimethylpropylmethylphosphonofluoridate) to facilitate the effects of endogenous ACh. Frequency receptive fields (FRF) were determined by presenting sequences of different isointensity tones before, during, and after application of ACh, MCh, eserine, or soman; also the cholinesterase blockers were applied between applications of ACh or MCh. The major effects produced by the inhibitors were similar to those of the agonists. Predominant effects were frequency-specific changes in FRF. Further, eserine and soman, similar to ACh and MCh, produced shifts in the best frequency (BF) of FRF due mainly to coordinated depression of responses to the BF and increased responses to adjacent, non-BF. The results indicate that exogenous and endogenus ACh, acting via muscarinic receptors, can significantly influence the physiological functioning of cortical neurons and consequently their processing of sensory information.