Progress in the Research of Lycopodium Alkaloids
Progress in the Research of Lycopodium Alkaloids
复制标题
DOI：
--
复制
发表时间：
2003
影响因子：
4.6
通讯作者：
Tan Chang
中科院分区：
文献类型：
--
作者：
Tan Chang
综述了1994年1月至2003年3月发现的石杉碱类生物碱，以及石杉碱A （HA）的研究进展。本文阐述了番茄碱型、番茄碱型、fawcettimini型和杂族这四种常见的番茄属生物碱的结构特征。药理学研究表明，透明质酸是一种有效的、高选择性的、可逆的乙酰胆碱酯酶（AChE）抑制剂。对HA的构效关系研究表明，HA具有简洁的结构，其大部分结构片段，如两个双键、吡酮环、三碳桥环和氨基的n原子是其具有高抗AchE活性所必需的。近年来，一些HA希夫碱衍生物和HA-tacrine杂交种被报道具有接近或优于HA的抗ache活性。
The Lycopodiwn alkaloids discovered from January, 1994 to March, 2003, and the research progress of huperzine A (HA) were reviewed. This paper illustrated the structure characters of lycopodine-type, lycodine-type, fawcettimine-type and miscellaneous group, common four types of Lycopodium alkaloids. Pharmacological studies showed HA was a potent, high selective, and reversible acetycholinesterase(AChE) inhibitor. The structure-activity relationship studies on HA disclosed that HA possesses a concise structure, in which most of structure fragments, such as two double bonds, pyridone ring, tri-carbon bridge ring, and the N-atom of the amino group were necessary for its high anti- AchE activity. Recently, some HA Schiff base derivatives and HA-tacrine hybrids were reported that they had near or better anti-AChE activity than HA.