Nonfasting low-density lipoprotein testing: Utility for cholesterol screening in pediatric primary care
Nonfasting low-density lipoprotein testing: Utility for cholesterol screening in pediatric primary care
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DOI：
10.1177/0009922806297752
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发表时间：
2007-06-01
影响因子：
1.6
通讯作者：
Bernstein, Henry
中科院分区：
文献类型：
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作者：
de Ferranti, Sarah;Shapiro, David;Bernstein, Henry
这项前瞻性研究评估了非空腹低密度脂蛋白胆固醇在儿科初级保健人群中的临床应用。根据美国儿科学会的定义，对4至12岁有高脂血症风险的健康儿童进行了均质直接低密度脂蛋白胆固醇检测，其中包括家族史不完整的患者。这种非空腹均一化验与改良的P定量相当，后者是测量低密度脂蛋白胆固醇的金标准参照法，也是目前推荐的筛查方法，总胆固醇。研究结果表明，这种非禁食测试可以为健康儿童提供更直接的低密度脂蛋白胆固醇测量，提高了临床实用性，并使患者在测试重要的胆固醇异常时更方便。
This prospective study assessed the clinical application of a nonfasting low-density lipoprotein cholesterol measure in a pediatric primary care population. A homogenous direct low-density lipoprotein cholesterol assay was tested in healthy children, aged 4 to 12 years, at risk for hyperlipidemia, as defined by American Academy of Pediatrics, and including patients with incomplete family histories. This nonfasting homogeneous assay was comparable to modified P quantification, the gold standard reference method of measuring low-density lipoprotein cholesterol, and the current recommended screening method, total cholesterol. Results from the study suggest that this nonfasting assay can provide more direct low-density lipoprotein cholesterol measurements for healthy children, with improved clinical utility and greater overall patient convenience in testing for important cholesterol abnormalities.