Early trabecular bone healing around titanium implants: A histologic study in rabbits
Early trabecular bone healing around titanium implants: A histologic study in rabbits
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DOI：
10.1902/jop.2007.060183
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发表时间：
2007-03-01
影响因子：
4.3
通讯作者：
Duyck, Joke
中科院分区：
文献类型：
--
作者：
Slaets, Elke;Carmeliet, Geert;Duyck, Joke
背景资料：一个详细的洞察骨小梁卸载钛implants.Methods的早期愈合反应：圆柱形植入物被插入在胫骨骨骺的兔子和左愈合I至42天。样本处理成石蜡或甲基丙烯酸甲酯切片和histomorphometricallyanalysed.Results：血肿后观察到的I和3天的种植体放置。此外，由于植入物安装程序，在植入物周围检测到小的骨小梁碎片。很快，破骨细胞被观察到再吸收这些碎片，而成骨细胞将它们合并成新骨股，从而使它们从第7天开始难以区分。此时，在原有骨的边缘检测到成骨细胞，积极沉积新骨，导致28天后种植体周围的类骨质沉积最大（58%）。在愈合7天后，周围骨中基本重塑单位的存在已经是最大的（P < 0.05，相对于t = 1和3天）。这种重塑活动，连同新骨形成，提供了一个坚定的锚定的植入物在trabecular bone.Conclusions：本研究评估了早期的细胞事件周围的骨小梁钛植入物。将植入物插入骨中会引发一系列生物学过程，包括血肿形成、植入部位附近的碎骨碎片、强烈的骨重塑和新骨形成，最终导致植入物的骨整合。
Background: A detailed insight into the early healing response of trabecular bone to unloaded titanium implants is lacking.Methods: Cylindrical implants were inserted in the tibial epiphysis of rabbits and left to heal for I to 42 days. Samples were processed into paraffin or methylmethacrylate sections and histomorphometrically analyzed.Results: A hematoma was observed after I and 3 days of implant placement. In addition, small fragments of bone trabeculae were detected around the implant as a result of the implant installment procedure. Soon, osteoclasts were observed resorbing these fragments, whereas osteoblasts incorporated them in strands of new bone, thereby making them difficult to distinguish from day 7 onward. At that time, osteoblasts were detected at the edges of the preexisting bone, actively depositing new bone, resulting in maximal osteoid deposition around the implant after 28 days (58%). After 7 days of healing, the presence of basic remodeling units in the surrounding bone was already maximal (P < 0.05 versus t = 1 and 3 days). This remodeling activity, together with the new bone formation, provided a firm anchoring of the implant in the trabecular bone.Conclusions: This study evaluated the early cellular events in trabecular bone surrounding titanium implants. The insertion of an implant into bone initiates a series of biologic processes, including the formation of a hematoma, shattered bone fragments adjacent to the implantation site, intensive bone remodeling, and the formation of new bone, eventually leading to the osseointegration of the implant.