Convergence of visual and whisker responses in the primary somatosensory thalamus (ventral posterior medial region) of the mouse.
Convergence of visual and whisker responses in the primary somatosensory thalamus (ventral posterior medial region) of the mouse.
复制标题
DOI：
10.1113/jp272791
复制
发表时间：
2017-02-01
期刊：
影响因子：
--
通讯作者：
Lucas RJ
中科院分区：
文献类型：
--
作者：
Allen AE;Procyk CA;Brown TM;Lucas RJ
使用体内电生理学，我们发现腹后内侧区（VPM）中的胡须反应神经元子集对视觉刺激做出反应。VPM中的这些光反应神经元对光流特别敏感。提出的光流刺激调制的幅度并发晶须反应。视觉信息通过环绕视觉皮层的回路到达VPM。这些数据代表了初级感觉丘脑中跨模态整合的新例子。感觉信号通过感觉特异性丘脑核团到达皮层。在这里，我们报告说，在初级感觉丘脑的小鼠触须系统（腹后内侧区; VPM）的神经元可以兴奋的视觉以及胡须刺激。使用细胞外电生理记录从麻醉小鼠，我们首先表明，简单的光的步骤可以激发一个子集的VPM神经元。然后，我们测试了VPM对空间模式做出反应的能力，并表明许多单元以方向选择的方式对视觉运动感到兴奋。多个物体的连贯运动（通常在头部旋转或身体运动期间发生的“光流”的人工再现）最好地参与这种视觉运动响应。我们接下来表明，当与视觉刺激共同应用时，在存在相反方向的光流的情况下，对触须偏转的反应幅度最高。重要的是，胡须反应幅度也调制的电影再现小鼠的视觉体验在自然探索行为。最后，我们提出的功能和解剖数据表明，从初级视觉皮层的功能连接（可能是多突触）VPM。这些数据提供了一个罕见的例子，多感觉整合发生在感觉丘脑的水平，并提供证据，根据视觉经验的动态调节胡须反应。使用体内电生理学，我们发现腹后内侧区（VPM）中的胡须反应神经元子集对视觉刺激做出反应。VPM中的这些光反应神经元对光流特别敏感。提出的光流刺激调制的幅度并发晶须反应。视觉信息通过环绕视觉皮层的回路到达VPM。这些数据代表了初级感觉丘脑中跨模态整合的新例子。
Using in vivo electrophysiology, we find that a subset of whisker‐responsive neurons in the ventral posterior medial region (VPM) respond to visual stimuli. These light‐responsive neurons in the VPM are particularly sensitive to optic flow. Presentation of optic flow stimuli modulates the amplitude of concurrent whisker responses. Visual information reaches the VPM via a circuit encompassing the visual cortex. These data represent a new example of cross‐modal integration in the primary sensory thalamus. Sensory signals reach the cortex via sense‐specific thalamic nuclei. Here we report that neurons in the primary sensory thalamus of the mouse vibrissal system (the ventral posterior medial region; VPM) can be excited by visual as well as whisker stimuli. Using extracellular electrophysiological recordings from anaesthetized mice we first show that simple light steps can excite a subset of VPM neurons. We then test the ability of the VPM to respond to spatial patterns and show that many units are excited by visual motion in a direction‐selective manner. Coherent movement of multiple objects (an artificial recreation of ‘optic flow’ that would usually occur during head rotations or body movements) best engages this visual motion response. We next show that, when co‐applied with visual stimuli, the magnitude of responses to whisker deflections is highest in the presence of optic flow going in the opposite direction. Importantly, whisker response amplitude is also modulated by presentation of a movie recreating the mouse's visual experience during natural exploratory behaviour. We finally present functional and anatomical data indicating a functional connection (probably multisynaptic) from the primary visual cortex to VPM. These data provide a rare example of multisensory integration occurring at the level of the sensory thalamus, and provide evidence for dynamic regulation of whisker responses according to visual experience. Using in vivo electrophysiology, we find that a subset of whisker‐responsive neurons in the ventral posterior medial region (VPM) respond to visual stimuli. These light‐responsive neurons in the VPM are particularly sensitive to optic flow. Presentation of optic flow stimuli modulates the amplitude of concurrent whisker responses. Visual information reaches the VPM via a circuit encompassing the visual cortex. These data represent a new example of cross‐modal integration in the primary sensory thalamus.