Nonicosahedral pathways for capsid expansion.
Nonicosahedral pathways for capsid expansion.
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用于衣壳扩张的非二十面体途径。
DOI：
10.1103/physreve.88.032710
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Cermelli P
中科院分区：
文献类型：
--
作者：
Cermelli P
对于相当数量的病毒来说，包裹病毒基因组的蛋白质容器的结构转变是生命周期的重要组成部分，也是病毒颗粒具有传染性的先决条件。尽管最近做出了许多努力，但这一过程的机制仍未完全了解，并且仍然缺乏对扩张途径的完整描述。我们在这里提出了一个粗粒度模型，该模型捕获了扩展过程的基本特征，并允许我们研究病毒衣壳变得不稳定的条件。基于该模型，我们证明了二十面体病毒衣壳的结构转变可能是通过低对称的局部膨胀事件级联发生的，这些事件以波状方式在衣壳表面扩散。
For a significant number of viruses a structural transition of the protein container that encapsulates the viral genome forms an important part of the life cycle and is a prerequisite for the particle becoming infectious. Despite many recent efforts the mechanism of this process is still not fully understood, and a complete characterization of the expansion pathways is still lacking. We present here a coarse-grained model that captures the essential features of the expansion process and allows us to investigate the conditions under which a viral capsid becomes unstable. Based on this model we demonstrate that the structural transitions in icosahedral viral capsids are likely to occur through a low-symmetry cascade of local expansion events spreading in a wavelike manner over the capsid surface.