Lactate stress testing in sporadic amyotrophic lateral sclerosis
Lactate stress testing in sporadic amyotrophic lateral sclerosis
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DOI：
10.1080/00207450590522847
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发表时间：
2005-04-01
影响因子：
2.2
通讯作者：
Finsterer, J
中科院分区：
文献类型：
--
作者：
Finsterer, J
线粒体功能障碍在ALS中经常观察到。线粒体功能障碍可能导致静息或低水平运动时血清乳酸增加，用于诊断目的。该研究调查了静息乳酸测定在证明ALS中线粒体功能障碍方面是否优于乳酸负荷试验（LST）上级。纳入15例ALS患者，4例女性，11例男性，年龄37-72岁。根据Norris评分评估疾病的严重程度。对照组包括66名健康受试者，女性40名，男性26名，年龄36-76岁。血清乳酸测定前，三次期间，和一次后，恒定的工作量与30 W的自行车测力计。根据ElEscorial标准，8例患者为确诊ALS，4例为很可能ALS，3例为可能ALS。2例患者的静息乳酸增加，1例明确，1例可能ALS。5例确诊患者LST异常，1例很可能患者LST异常，1例可能患者LST异常。LST异常患者的平均Norris评分为67.8分，LST正常患者的平均Norris评分为74.6分。总之，LST比静息乳酸测定更适合于显示ALS患者的线粒体功能障碍。LST提示半数ALS患者存在线粒体功能障碍。ALS中的线粒体功能障碍与疾病的临床严重程度有关。
Mitochondrial dysfunction is frequently observed in ALS. Mitochondrial dysfunction may result in increased serum lactate at rest or low levels of exercise, being used for diagnostic purposes. The study investigated if resting-lactate-determination is superior to lactate-stress-testing (LST) in demonstrating mitochondrial dysfunction in ALS. Included were 15 ALS patients, 4 women, 11 men, aged 37-72. Severity of the disease was assessed by the Norris-score. The control group comprised 66 healthy subjects, 40 women, 26 men, aged 36-76. Serum lactate was determined before, three times during, and once after a constant workload with 30 W on a bicycle ergometer. According to the ElEscorial criteria 8 patients had definite, 4 probable, 3 possible ALS. Resting lactate was increased in 2 patients, 1 with definite and 1 with possible ALS. The LST was abnormal in 5 patients with definite, I with probable and I with possible ALS. The mean Norris-score was 67.8 in patients with abnormal LST and 74.6 in patients with normal LST. In conclusion, the LST is more suitable than restinglactate-determination in demonstrating mitochondrial dysfunction in ALS. The LST suggests mitochondrial dysfunction in half of the ALS patients. Mitochondrial dysfunction in ALS is related to the clinical severity of the disease.