A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity
A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity
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DOI：
10.1016/j.clnu.2014.10.004
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发表时间：
2015-10-01
影响因子：
6.3
通讯作者：
Trindade, Erasmo B. S. M.
中科院分区：
文献类型：
--
作者：
Beserra, Bruna T. S.;Fernandes, Ricardo;Trindade, Erasmo B. S. M.
背景和目标：几项研究报告了益生元和合生元补充剂对血脂和葡萄糖稳态的影响，但是尚未在超重或肥胖个体中进行评估这些参数的临床试验的汇总分析。本研究的目的是评价益生元和合生元对超重或肥胖成人血脂谱、空腹胰岛素和空腹血糖的影响。方法：系统检索2014年5月前的电子数据库和筛选参考文献列表中的随机对照试验。结果：共纳入13个试验，代表513名体重指数>= 25 kg/m2的成年受试者。补充益生元可降低血浆总胆固醇（SMD -0.25; 95% CI-0.48，-0.02）和LDL-c总体分析中的（SMD -0.22; 95% CI-0.44，-0.00）浓度和甘油三酯降低（SMD -0.72; 95% CI-1.20，-0.23）和HDL-c浓度升高（SMD 0.49; 95% CI 0.01，0.97）。合生元补充降低血浆空腹胰岛素（SMD-0. 39; 95% CI-0. 75，-0. 02）和甘油三酯（SMD-0. 43; 95% CI-0. 70，-0. 15）concentration.Conclusions：评价参数的改善支持益生元和合生元补充作为肥胖相关合并症（如血脂异常和胰岛素抵抗）的辅助治疗。(C)2014爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: Several studies have reported the effects of prebiotics and synbiotics supplementation in lipid profile and glucose homeostasis, however a pooled analysis of clinical trials that assessed these parameters has not been performed in overweight or obese individuals. The aim of this study was to evaluate the effects of prebiotics and synbiotics on plasma lipid profile, fasting insulin and fasting glucose in adults with overweight or obesity.Methods: Randomized controlled trials were systematically searched before May 2014 in electronic databases and screening reference lists. Combined and stratified (diabetics and non-diabetics trials) meta-analyzes were performed.Results: Thirteen trials, representing 513 adult participants with Body Mass Index >= 25 kg/m(2) were included. Prebiotic supplementation reduced plasma total cholesterol (SMD -0.25; 95% CI -0.48, -0.02) and LDL-c (SMD -0.22; 95% CI -0.44, -0.00) concentrations in overall analysis, and reduced triglycerides (SMD -0.72; 95% Cl -1.20, -0.23) and increased HDL-c (SMD 0.49; 95% CI 0.01, 0.97) concentrations in diabetic trials. Synbiotic supplementation reduced plasma fasting insulin (SMD -0.39; 95% CI -0.75, -0.02) and triglycerides (SMD -0.43; 95% CI -0.70, -0.15) concentrations.Conclusions: The improvement of the evaluated parameters supports prebiotics and synbiotics supplementation as an adjuvant therapy in obesity-related comorbidities, such as dyslipidemia and insulin resistance. (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.