Regulation of kinetochore-microtubule attachments by Aurora B kinase
Regulation of kinetochore-microtubule attachments by Aurora B kinase
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DOI：
10.1042/bst0370976
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发表时间：
2009-10-01
影响因子：
3.9
通讯作者：
Lampson, Michael A.
中科院分区：
文献类型：
--
作者：
Liu, Dan;Lampson, Michael A.
有丝分裂中染色体的精确分离需要纺锤体微管将姐妹着丝点连接到有丝分裂纺锤体的相反两极（双向）。为了实现所有染色体的双向定向，错误的附着物被选择性地破坏，为双向定向提供了新的机会，而正确的附着物则被稳定。当纺锤体微管将双取向的姐妹着丝点拉向相反的方向时，着丝粒上的张力可能是区分不同附着状态的信号。不正确的附着不稳定需要Ipl1/Aurora B激酶，它磷酸化与微管直接相互作用的着丝点底物。目前的综述主要集中在Aurora B如何调节着丝点张力的附着物。
Accurate segregation of chromosomes in mitosis requires that spindle microtubules attach sister kinetochores to opposite poles of the mitotic spindle (biorientation). To achieve biorientation of all chromosomes, incorrect attachments are selectively destabilized, providing a fresh opportunity to biorient, whereas correct attachments are stabilized. Tension across the centromere may be the signal that distinguishes different attachment states, as spindle microtubules pull bioriented sister kinetochores in the opposite direction. Destabilization of incorrect attachments requires the Ipl1/Aurora B kinase, which phosphorylates kinetochore substrates that directly interact with microtubules. The present review focuses on how Aurora B regulates attachments in response to centromere tension.