Topography of callosal atrophy reflects distribution of regional cerebral volume reduction in Alzheimer's disease
Topography of callosal atrophy reflects distribution of regional cerebral volume reduction in Alzheimer's disease
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DOI：
10.1016/s0925-4927(99)00018-9
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发表时间：
1999-06-30
影响因子：
2.3
通讯作者：
Knopp, MV
中科院分区：
文献类型：
--
作者：
Pantel, J;Schröder, J;Knopp, MV
已经提出，阿尔茨海默病（AD）中的区域胼胝体萎缩可以作为新皮层中神经元损失的体内指标。在这项研究中，总的和区域的胼胝体的大小进行了评估，相对于体积的额，颞，顶叶在38例AD（NINCDS-ADRDA标准）使用定量磁共振成像。20名年龄和性别匹配的健康受试者作为对照组。使用基于个人计算机的软件通过手动追踪进行所有定量测量。总尺寸和五个测量的区域子部分显着较小的AD相比，对照组。痴呆的严重程度与胼胝体中段（吻侧体和中体）的大小显著相关。在AD组中，胼胝体的吻侧体与额叶体积显著相关，中间体与颞叶体积相关，压部的大小与顶叶体积相关。我们的结论是，AD的胼胝体萎缩反映了皮质神经元损伤的严重程度和模式。区域胼胝体萎缩和痴呆严重程度之间的相关性表明，大脑半球间皮质-皮质分离可能有助于痴呆综合征。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
It has been suggested that regional corpus callosum atrophy in Alzheimer's disease (AD) may serve as an in vivo index of neuronal loss in the neocortex. In this study total and regional size of the corpus callosum was evaluated with respect to the volumes of the frontal, temporal, and parietal lobes in 38 patients with AD (NINCDS-ADRDA criteria) using quantitative magnetic resonance imaging. Twenty healthy subjects matched for age and gender served as a control group. Al quantitative measurements were performed by manual tracing using personal computer-based software. Both total size and the five measured regional subsections were significantly smaller in AD when compared to the control subjects. The severity of dementia was significantly correlated with the size of the middle sections of the corpus callosum (rostral body and midbody). Within the AD group, the rostral body of the corpus callosum was significantly correlated with the frontal lobe volumes, the midbody was correlated with the temporal lobe volumes, and size of the splenium was correlated with the parietal lobe volumes. We conclude that callosal atrophy in AD reflects the severity and pattern of cortical neuronal damage. Correlations between regional callosal atrophy and severity of dementia indicate that interhemispheric cortico-cortical disconnection may contribute to the dementia syndrome. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.