Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
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DOI：
10.3390/jcm9030883
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发表时间：
2020-03-01
影响因子：
3.9
通讯作者：
Shin, Yong Un
中科院分区：
文献类型：
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作者：
Park, Seung Hun;Cho, Heeyoon;Shin, Yong Un
在这项横断面研究中，我们检查了100名年龄在5至80岁之间的健康参与者的视网膜血管的年龄相关变化，并将其分为四组（G1, 20岁以下；G2, 20至39岁；G3, 40至59岁；G4, 60岁或以上）。所有受试者均接受了扫源光学相干断层扫描（SS-OCT）和OCT血管造影（OCTA）。用OCTA测量浅、深毛细血管丛（DCP）及绒毛膜毛细血管（CCP）的血管密度（VD）。比较各年龄组毛细血管层血管密度、中央凹无血管区（FAZ）面积、神经节细胞-内丛状层（GC-IPL）厚度、视网膜厚度（RT）、脉络膜厚度（CT）。大部分OCT变量与OCTA变量相关。FAZ区域；SCP、DCP、CCP的VD；GC-IPL厚度;RT;除中心GC-IPL厚度（p = 0.14）和中心RT （p = 0.25）外，G1 + G2与G3 + G4间CT差异均有统计学意义（p < 0.001）。40岁后视网膜毛细血管密度降低，FAZ面积增大，标志着中年的开始。
In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 years of age; G4, age 60 years or older). All subjects underwent swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). The vascular density (VD) of the superficial (SCP) and deep capillary plexus (DCP), and choriocapillaris (CCP) were measured using OCTA. The vascular density of each capillary layer, foveal avascular zone (FAZ) area, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), and choroidal thickness (CT) were compared between age groups. Most OCT variables were correlated with OCTA variables. The FAZ area; VD of the SCP, DCP, and CCP; GC-IPL thickness; RT; and CT showed significant difference (p < 0.001) between G1 + G2 and G3 + G4, except for central GC-IPL thickness (p = 0.14) and central RT (p = 0.25). Density of the retinal capillary vasculature reduced and FAZ area increased after age 40, which represents the onset of middle age.