Biomarker Enrichment in Sepsis-Associated Acute Kidney Injury: Finding High-Risk Patients in the Intensive Care Unit.
Biomarker Enrichment in Sepsis-Associated Acute Kidney Injury: Finding High-Risk Patients in the Intensive Care Unit.
复制标题
脓毒症相关急性肾损伤的生物标志物富集：在重症监护病房寻找高风险患者。
DOI：
10.1159/000534608
复制
发表时间：
2024
影响因子：
4.2
通讯作者：
Koyner,JayL
中科院分区：
文献类型：
--
作者：
Baeseman,Louis;Gunning,Samantha;Koyner,JayL
Background: Sepsis associated Acute kidney injury (AKI) is a leading comorbidity in admissions to the intensive care unit. While a gold standard definition exists, it remains imperfect and does not allow for the timely identification of patients in the setting of critical illness. This review will discuss the use of biochemical and electronic biomarkers to allow for prognostic and predictive enrichment of patients with sepsis associated AKI over and above the use of serum creatinine and urine output. Summary: Current data suggest that several biomarkers are capable of identifying patients with sepsis at risk for the development of severe AKI and other associated morbidity. This review discusses this data and these biomarkers in the setting of sub-phenotyping and endotyping sepsis associated AKI. While not all these tests are widely available and some require further validation, in the near future we anticipate several new tools to help nephrologists and other providers better care for patients with sepsis associated AKI.
