ABSORPTION EXCRETION AND HALF-LIFE OF CLINIMYCIN IN NORMAL ADULT MALES
ABSORPTION EXCRETION AND HALF-LIFE OF CLINIMYCIN IN NORMAL ADULT MALES
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DOI：
10.1097/00000441-196807000-00004
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发表时间：
1968-01-01
影响因子：
3.1
通讯作者：
LUMMIS, WL
中科院分区：
文献类型：
--
作者：
WAGNER, JG;NOVAK, E;LUMMIS, WL
本文来自Upjohn公司医学研究部。克林霉素是林可霉素的衍生物，是7（S）-氯-7-脱氧林可霉素盐酸盐水合物，其体外抗菌活性高于林可霉素，特别是对葡萄球菌的抗菌活性更强。本文仅报告了一项在年轻正常成年男性中进行的药理学研究。简言之，它表明克林霉素吸收非常迅速，在空腹受试者中在45分钟内达到峰值水平：其半衰期为2.38小时，林可霉素的半衰期据报道为5.2小时。在4个不同的进餐时间给药表明，食物只会延迟吸收，不会损害吸收。胶囊和片剂的吸收同样良好。仅约10%或更少的剂量从尿液中回收：其余部分的命运无法解释。这些发现得到了非常详细的报道，并且由于体内形成了林可霉素的一种已知衍生物和“可能一种或多种”未知衍生物这一事实而变得复杂：第二系列测定是使用仅含有克林霉素的血清或尿液提取物进行的。L. P.加罗德
This paper is from the Medical Research Division of the Upjohn Company. Clinimycin, a derivative of lincomycin, is 7(S)-chloro-7-deoxylincomycin hydrochloride hydrate, and has been shown to possess higherin vitroantibacterial activity than lincomycin, especially against staphylococci. This paper reports only a pharmacological study in young normal adult males. Briefly, it shows that Clinimycin is very rapidly absorbed, the peak level being reached in 45 minutes in fasting subjects: its half-life is 2.38 hours, that of lincomycin being reported to be 5.2 hours. Administration at 4 different times in relation to a meal showed that food only delayed absorption and did not impair it. It was equally well absorbed from capsules and tablets. Only about 10% or less of the dose was recovered from the urine: the fate of the remainder is unexplained. The findings are reported in great detail, and are complicated by the fact that one known and " possibly one or more" unknown derivatives of lincomycin are formed in the body: a second series of assays was done with extracts of serum or urine containing Clinimycin only. L.P. Garrod.