Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors
Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors
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DOI：
10.1097/00000478-199810000-00012
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发表时间：
1998-10-01
影响因子：
5.6
通讯作者：
Brambilla, E
中科院分区：
文献类型：
--
作者：
Lantuejoul, S;Moro, D;Brambilla, E
神经细胞黏附分子(NCAM)是肺癌神经内分泌(NE)分化的特异性标志物。因为聚唾液酸形式(NCAM-PSA)降低了粘附性，我们假设NCAM-PSA的表达可能有利于转移扩散。本文比较了120例NE肺癌(17例典型类癌、3例不典型类癌、30例大细胞NE癌和70例小细胞肺癌)中NCAM和NCAM-PSA的免疫染色，并与25例腺癌和25例鳞癌进行了比较。神经细胞黏附分子在腺癌和鳞癌中均为阴性，但在从典型类癌到小细胞肺癌的所有NE肿瘤中持续表达。NCAM-PSA在高级别肺癌中的表达显著高于类癌，其中大细胞肺癌阳性24例，小细胞肺癌阳性65例，典型类癌阳性10例，非典型类癌阳性2例。神经细胞黏附分子-聚唾液酸型染色评分在高级别肿瘤中显著高于低级别肿瘤(p=0.002)，并与组织学类型间的淋巴结转移(p=0.04)和转移(p=0.016)有关，但与个体肿瘤类型无关。我们的结论是，NCAM-PSA在NE肺肿瘤中具有低分化和侵袭性的临床行为，但不能被视为单个肿瘤类别的预后因素。
Neural cell adhesion molecules (NCAM) represent specific markers of neuroendocrine (NE) differentiation in lung cancer. Because the polysialic acid form (NCAM-PSA) has reduced adhesion properties, we hypothesized that NCAM-PSA expression could favor metastatic spread. Immunostaining of NCAM and NCAM-PSA were therefore compared in 120 NE lung tumors, including 17 typical carcinoids, 3 atypical carcinoids, 30 large cell NE carcinomas and 70 small cell lung carcinomas, as compared with 25 adenocarcinomas and 25 squamous cell carcinomas. Neural cell adhesion molecules were negative in adenocarcinomas and squamous cell carcinomas but were constantly expressed in all NE tumors from typical carcinoids to small cell lung carcinomas. NCAM-PSA expression was significantly mon frequent in high-grade tumors, with 24 of 30 positive cases in large cell NE carcinomas and 65 of 70 positive cases in small cell lung carcinoma, than in carcinoids with 10 of 17 and 2 of 3 positive cases in typical carcinoids and atypical carcinoids, respectively. The neural cell adhesion molecule-polysialic acid form scores of staining were significantly higher in high-grade as compared with low-grade tumors (p = 0.002), and were correlated with nodal spread (p = 0.04) and metastasis (p = 0.016) across histologic classes but not in individual tumor type. We conclude that NCAM-PSA connotes poor differentiation and aggressive clinical behavior in the spectrum of NE lung tumors, but cannot be regarded as a prognostic factor in individual tumor classes.