The genetic mediation of individual differences in sensitivity to pain and its inhibition
The genetic mediation of individual differences in sensitivity to pain and its inhibition
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DOI：
10.1073/pnas.96.14.7744
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发表时间：
1999-07-06
影响因子：
11.1
通讯作者：
Mogil, JS
中科院分区：
文献类型：
--
作者：
Mogil, JS
疼痛相关特征的个体间差异性的潜在基础开始被揭示。虽然基因与人类疼痛感知经验的相对重要性尚不清楚，啮齿动物种群显示伤害性和镇痛敏感性的大和遗传的差异。特别是不同的人群的识别和表征提供了一个强大的初始步骤，在疼痛的遗传分析，因为这些模型可以被用来识别基因的行为水平的变异性。最终，可以鉴定代表疼痛相关基因的差异等位基因的DNA序列差异。因此，通过结合使用“自上而下”和“自下而上”的策略，我们现在能够从基因上剖析甚至像疼痛这样复杂的生物特征。本综述总结了目前在人类和啮齿动物中实现这些目标的进展。
The underlying bases of the considerable interindividual variability in pain-related traits are starting to be revealed. Although the relative importance of genes versus experience in human pain perception remains unclear, rodent populations display large and heritable differences in both nociceptive and analgesic sensitivity. The identification and characterization of particularly divergent populations provides a powerful Initial step in the genetic analysis of pain, because these models can be exploited to identify genes contributing to the behavior-level variability. Ultimately, DNA sequence differences representing the differential alleles at pain-relevant genes can be identified. Thus, by using a combination of "top-down" and "bottom-up" strategies, we are now able to genetically dissect even complex biological traits like pain. The present review summarizes the current progress toward these ends in both humans and rodents.