Spatiotemporal Distribution of Linear Microcracks and Diffuse Microdamage Following Daily Bouts of Fatigue Loading of Rat Ulnae
Spatiotemporal Distribution of Linear Microcracks and Diffuse Microdamage Following Daily Bouts of Fatigue Loading of Rat Ulnae
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大鼠尺骨每日疲劳负荷后线性微裂纹和弥漫性微损伤的时空分布
DOI：
10.1002/jor.24391
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发表时间：
2019-06
期刊：
影响因子：
--
通讯作者：
Jing D
中科院分区：
文献类型：
--
作者：
Liu X;Tang C;Zhang X;Cai J;Yan Z;Xie K;Yang Z;Wang J;Guo XE;Luo E;Jing D
Microdamage accumulation contributes to impaired skeletal mechanical integrity. The bone can remove microdamage by initiating targeted bone remodeling. However, the spatiotemporal characteristics of microdamage initiation and propagation and their relationship with bone remodeling in response to fatigue loading, especially for more physiologically relevant daily bouts of compressive loading, remain poorly understood. The right forelimbs of 24 rats were cyclically loaded with a ramp waveform for 1,500 cycles/day, and contralateral ulnae were not loaded as the controls. The rats were divided into four equal groups and loaded for 1, 4, 7, and 10 days, respectively. We demonstrated that linear microcracking accumulation exhibited a non‐linear time‐varying process within 10 days of loading with peaked microcrack density at Day 7. Disrupted canaliculi surrounding linear microcracks showed high similarity with the temporal changes of linear microcracking accumulation. Observable intracortical resorption regions were found on Day 10. We found more linear microcracks accumulated in the tensile cortex, but longer cracks were observed in the compressive sides. Increased accumulation of diffuse microdamage was observed from Day 4, but no obvious peak was observed within the 10‐day loading period. Diffuse damage first initiated in the compressive cortices but extended to tension from Day 7. The diffuse damage exhibited no impacts on the surrounding osteocyte integrity. Together, our findings revealed a time‐dependent, bone remodeling‐mediated varying process of linear microcracking accumulation following daily bouts of fatigue loading (with observable peak at Day 7 under our loading regime). Our study also identified distinct spatial accumulation of linear and diffuse microdamage in rat ulnae with tensile and compressive strains. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2112–2121, 2019
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DOI：
10.1155/2014/282980
发表时间：
2014
期刊：
Journal of sports medicine (Hindawi Publishing Corporation)
影响因子：
--
作者：
Wood AM;Hales R;Keenan A;Moss A;Chapman M;Davey T;Nelstrop A
通讯作者：
Nelstrop A
影响因子：
4.1
作者：
Deepak Vashishth;J. Koontz;Shijing Qiu;D. Lundin-Cannon;Y. Yeni;Mitchell B. Schaffler;David P. Fyhrie
通讯作者：
Deepak Vashishth;J. Koontz;Shijing Qiu;D. Lundin-Cannon;Y. Yeni;Mitchell B. Schaffler;David P. Fyhrie
影响因子：
6.2
作者：
B. Uthgenannt;Michael H Kramer;Joyce A Hwu;B. Wopenka;Matthew J. Silva
通讯作者：
B. Uthgenannt;Michael H Kramer;Joyce A Hwu;B. Wopenka;Matthew J. Silva
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影响因子：
3.1
作者：
Chen, Jing;Cheng, Hao;Xiong, Wei
通讯作者：
Xiong, Wei
影响因子：
4.1
作者：
MORI, S;BURR, DB
通讯作者：
BURR, DB