Directly photopatterning of polycaprolactone-derived photocured resin by UV-initiated thiol-ene "click" reaction: Enhanced mechanical property and excellent biocompatibility
Directly photopatterning of polycaprolactone-derived photocured resin by UV-initiated thiol-ene "click" reaction: Enhanced mechanical property and excellent biocompatibility
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通过紫外线引发的硫醇-烯“点击”反应直接对聚己内酯衍生的光固化树脂进行光图案化：增强的机械性能和优异的生物相容性
DOI：
10.1016/j.cej.2019.02.045
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发表时间：
2019
影响因子：
15.1
通讯作者：
Chang Lingqian
中科院分区：
文献类型：
--
作者：
Zhu Yazhi;Shen Jian;Yin Li;Wei Xiaojuan;Chen Feng;Zhong Mingqiang;Gu Zheng;Xie Yao;Jin Wei;Liu Zhenjie;Chitrakar Ch;ani;Chang Lingqian
本文报道了一种新的路线，用于制造聚己内酯衍生的（PCL衍生的）光固化材料的交联季戊四醇四（PETMP）具有增强的机械性能和良好的生物相容性。光固化材料通过紫外线照射通过硫醇-烯“点击”化学交联。该技术的主要新奇在于使用光刻法容易地制造高分辨率图案（105 μm），并且不添加光引发剂。研究了光固化材料的热性能、力学性能和细胞相容性。DSC和DMA分析表明，PCL光固化材料的柔韧性和韧性都有所提高。因此，PCL衍生的光固化材料实现了增强的机械性能（随着PCL链段含量从0增加到38.0%，光固化样品的断裂强度从0.62单调增加到3.10 MPa，杨氏模量从1.39单调增加到9.22 MPa）。由于掺入了PCL衍生的共聚物，该材料显示出对细胞的优异亲和力，这通过细胞增殖和LDH释放来证明。PCL衍生的光固化材料的溶血率均<5%，而PEGDA光固化材料的溶血率为约17%。还可以观察到，与PEGDA相比，PCL衍生的光固化材料将改善生物相容性并降低生物毒性。这种合成具有微米分辨率图案的生物相容性光固化树脂的简便路线在生物工程和生物医学领域具有良好的影响。
This paper reports a novel routine for the fabrication of a polycaprolactone-derived (PCL-derived) photocured material cross-linked by pentaerythritol tetra (PETMP) with enhanced mechanical property and excellent biocompatibility. The photocured material is cross-linkedviaUV irradiation through thiol-ene “click” chemistry. The main novelty of this technique is the facile fabrication of high-resolution patterns (∼5 μm) using photolithography, and without adding photo-initiators. The photocured material is studied regarding to its thermal property, mechanical property and cytocompatibility. DSC and DMA suggest that the flexibility and toughness of PCL-derived photocured material have improved. Accordingly, the PCL-derived photocured material achieves enhanced mechanical property (with the increase of PCL segment content from 0 to 38.0%, the photocured samples monotonically increased their breaking strength from 0.62 to 3.10 MPa and Young’s modulus from 1.39 to 9.22 MPa). Due to the incorporation of the PCL-derived copolymer, the material shows excellent affinity to cells, which is demonstrated by the cell proliferation and release of LDH. The hemolysis ratio of PCL-derived photocured materials is all <5%, while the PEGDA photocured material is ∼17%. It can also be observed that PCL-derived photocured material will improve the biocompatibility and reduce biotoxicity compared with PEGDA. This facile route for synthesis of biocompatible photocured resin with micrometer-resolute patterns has a good impact in bioengineering and biomedical fields.