Experience-Dependent Intrinsic Plasticity During Auditory Learning
Experience-Dependent Intrinsic Plasticity During Auditory Learning
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DOI：
10.1523/jneurosci.1036-18.2018
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发表时间：
2019-02-13
影响因子：
5.3
通讯作者：
Hyson, Richard L.
中科院分区：
文献类型：
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作者：
Ross, Matthew T.;Flores, Diana;Hyson, Richard L.
斑马雀(Taeniopygia Guttata)的歌曲学习需要接触到导师的歌曲，从而产生听觉记忆。这种记忆是后来感觉运动学习的基础，从而产生了导师的歌曲的副本。皮质运动前核HVC(专有名称)是听觉和感觉运动学习以及最终产生成人歌曲所必需的。我们最近发现，HVC神经元的内在生理学在歌曲学习的各个阶段都会发生变化，但这些变化是学习的结果还是独立于经验的发育变化？为了测试听觉经验在驱动内在变化中的作用，进行了膜片钳实验，比较了不同家教暴露量下幼鸟的HVC神经元。HVC神经元的内在生理学随着导师的暴露而改变。与直觉相反的是，家教剥夺导致幼年HVC神经元表现出成人型的表型，这在家教暴露的青少年中是不存在的。生物物理模型被开发来预测哪些离子通道受到经验的调制。这些模型表明，家教暴露可瞬时抑制以基底神经节为靶点的HVC神经元的I-h和T型钙电流，而家教暴露可增加HVC神经元的静息膜电位，降低驱动鸣唱的HVC神经元的峰波幅度。我们的发现表明，内在可塑性可能是HVC听觉学习机制的一部分。更广泛地说，学习和记忆模型应该将内在可塑性作为神经系统编码经验持久影响的一种可能机制。
Song learning in zebra finches (Taeniopygia guttata) requires exposure to the song of a tutor, resulting in an auditory memory. This memory is the foundation for later sensorimotor learning, resulting in the production of a copy of the tutor's song. The cortical premotor nucleus HVC (proper name) is necessary for auditory and sensorimotor learning as well as the eventual production of adult song. We recently discovered that the intrinsic physiology of HVC neurons changes across stages of song learning, but are those changes the result of learning or are they experience-independent developmental changes? To test the role of auditory experience in driving intrinsic changes, patch-clamp experiments were performed comparing HVC neurons in juvenile birds with varying amounts of tutor exposure. The intrinsic physiology of HVC neurons changed as a function of tutor exposure. Counterintuitively, tutor deprivation resulted in juvenile HVC neurons showing an adult-like phenotype not present in tutor-exposed juveniles. Biophysical models were developed to predict which ion channels were modulated by experience. The models indicate that tutor exposure transiently suppressed the I-h and T-type Ca2+ currents in HVC neurons that target the basal ganglia, whereas tutor exposure increased the resting membrane potential and decreased the spike amplitude in HVC neurons that drive singing. Our findings suggest that intrinsic plasticity may be part of the mechanism for auditory learning in the HVC. More broadly, models of learning and memory should consider intrinsic plasticity as a possible mechanism by which the nervous system encodes the lasting effects of experience.