Author Correction: Stress fibres are embedded in a contractile cortical network
Author Correction: Stress fibres are embedded in a contractile cortical network
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作者更正：应力纤维嵌入收缩皮质网络中
DOI：
10.1038/s41563-020-00862-8
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发表时间：
2021
期刊：
影响因子：
41.2
通讯作者：
Kurzawa, Laetitia
中科院分区：
文献类型：
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作者：
Vignaud, Timothée;Copos, Calina;Leterrier, Christophe;Toro-Nahuelpan, Mauricio;Tseng, Qingzong;Mahamid, Julia;Blanchoin, Laurent;Mogilner, Alex;Théry, Manuel;Kurzawa, Laetitia
收缩肌球蛋白网络负责细胞内力的产生。越来越多的证据表明，肌动蛋白细丝束与网络的其余部分形成相互连接和相互转换的结构。在这项研究中，我们探索了这些互连对整个细胞中牵引力的产生和分布的机械影响。利用水凝胶微图案化、牵引力显微镜和激光消融相结合的方法，我们测量了局部光消融时牵引力的松弛。我们的实验结果和对网络机械响应的模拟表明，束沿其全长完全嵌入到连续且可收缩的皮质细丝网络中。此外，这些束的收缩在整个细胞中的传播依赖于这种嵌入。此外，这些束似乎起源于周围网状物中薄而未附着的皮质肌动蛋白细丝的排列和结合。
Contractile actomyosin networks are responsible for the production of intracellular forces. There is increasing evidence that bundles of actin filaments form interconnected and interconvertible structures with the rest of the network. In this study, we explored the mechanical impact of these interconnections on the production and distribution of traction forces throughout the cell. By using a combination of hydrogel micropatterning, traction force microscopy and laser photoablation, we measured the relaxation of traction forces in response to local photoablations. Our experimental results and modelling of the mechanical response of the network revealed that bundles were fully embedded along their entire length in a continuous and contractile network of cortical filaments. Moreover, the propagation of the contraction of these bundles throughout the entire cell was dependent on this embedding. In addition, these bundles appeared to originate from the alignment and coalescence of thin and unattached cortical actin filaments from the surrounding mesh.