A novel clinical role for angiopoietin-1 in malignant pleural mesothelioma
A novel clinical role for angiopoietin-1 in malignant pleural mesothelioma
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DOI：
10.1183/09031936.00154009
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发表时间：
2010-11-01
影响因子：
24.3
通讯作者：
Nakano, T.
中科院分区：
文献类型：
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作者：
Tabata, C.;Hirayama, N.;Nakano, T.
恶性胸膜间皮瘤（MPM）是一种与石棉暴露相关的侵袭性恶性肿瘤，对常规治疗的反应有限;因此，早期诊断MPM非常重要。我们以前曾报道过血管生成素（Angiopoietin，Ang）-1与博莱霉素诱导的肺纤维化有关，在此，我们研究了Ang-1与MPM细胞（来源于与肺成纤维细胞相似的间充质细胞）发育的关系，并证实了Ang-1在体外刺激MPM细胞的生长和迁移。我们还证明，与接触石棉但未发生MPM的人群相比，MPM患者的血清Ang-1水平显著升高。晚期MPM患者的血清Ang-1水平高于早期MPM患者，Kaplan-Meier方法显示血清Ang-1水平与生存率显著相关，我们提出Ang-1在MPM肿瘤生长中起重要作用的可能性，我们的数据表明，血清Ang-1浓度可能是有用的预后因素。
Malignant pleural mesothelioma (MPM) is an aggressive malignant tumour associated with asbestos exposure that has only a limited response to conventional therapy; therefore, diagnosing MPM early is very important. We have previously reported that angiopoietin (Ang)-1 was correlated with bleomycin-induced pulmonary fibrosis.Here, we investigated the association of Ang-1 with the development of MPM cells, which originate from mesenchymal cells similar to lung fibroblasts, and demonstrated that Ang-1 stimulated the growth and migration of MPM cells in vitro. We also demonstrated that patients with MPM had significantly higher serum levels of Ang-1 in comparison to a population who had been exposed to asbestos but had not developed MPM. The patients with advanced-stage MPM showed higher levels of Ang-1 than the early-stage MPM patients and the Kaplan-Meier method revealed a significant correlation between serum Ang-1 levels and survival.We propose the possibility that Ang-1 plays an important role in MPM tumour growth and our data suggest that the serum concentration of Ang-1 could be useful as prognostic factor.