Ototoxicity following pediatric hematopoietic stem cell transplantation: A prospective cohort study
Ototoxicity following pediatric hematopoietic stem cell transplantation: A prospective cohort study
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DOI：
10.1002/pbc.20036
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发表时间：
2004-06-01
影响因子：
3.2
通讯作者：
Sung, L
中科院分区：
文献类型：
--
作者：
Punnett, A;Bliss, B;Sung, L
背景我们的目的是描述儿童干细胞移植（SCT）后听力恶化的频率并确定其危险因素。方法.在这项前瞻性队列研究中，我们在SCT前后进行了纯音测听和耳声发射（OAE）测量。听力恶化被认为是听力测定或OAE的恶化。结果2000年10月至2002年11月，45信息测听或OAE结果。这些儿童中有20/45（44%）在SCT后听力恶化。SCT后听力较差的患者更可能患有神经母细胞瘤（比值比[OR] 16.0 [95% CI 1.8，143.2; P = 0.003]）。接受卡铂预处理（OR 7.7 [95% CI 1.4，41.9; P 0.01]），基线听力异常（OR 5.1 [95% CI 1.3，19.5; P=0.02]），基线血清肌酐较高（血清肌酐每增加5 mumol/L，OR为1.5 [95% CI 1.03，2.1; P- 0.03]）。结论许多接受SCT的儿童在SCT后听力会恶化。一个高风险组的儿童可以划定谁可能受益于更密集的听力监测后SCT。(C)2004威利-利斯公司
Background. Our objectives were to describe the frequency and determine risk factors for hearing deterioration following pediatric stern cell transplantation (SCT). Methods. In this prospective cohort Study, we performed pure tone audiometry and measured otoacoustic emissions (OAE) prior to and following SCT. Worse hearing was considered deterioration in either audiometry or OAE. Results. Between October 2000 and November 2002, 45 informative audiometry or OAE results were obtained. Hearing deteriorated following SCT in 20/45 (44%) of these children. Those with worse hearing following SCT were more likely to have neuroblastoma (odds ratio [OR] 16.0 [95% Cl 1.8, 143.2; P = 0.003]). receive carboplatin conditioning (OR 7.7 [95% Cl 1.4, 41.9; P 0.01]), have abnormal baseline hearing (OR 5.1 [95% Cl 1.3, 19.5; P=0.02]), and have higher baseline serum creatinine (OR for every increase of 5 mumol/L of serum creatinine of 1.5 [95% Cl 1.03, 2.1; P- 0.03]). Conclusion. Many children who undergo SCT will have deterioration in hearing following SCT. A high-risk group of children can be delineated who may benefit from more intensive audiological monitoring following SCT. (C) 2004 Wiley-Liss, Inc.