Changes in iron metabolism centered on hepcidin due to high-intensity exercise under restricted food intake
Changes in iron metabolism centered on hepcidin due to high-intensity exercise under restricted food intake
复制标题
限制食物摄入下高强度运动导致以铁调素为中心的铁代谢变化
DOI：
10.1016/j.nut.2021.111179
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发表时间：
2021
期刊：
影响因子：
4.4
通讯作者：
Kuwahata Masashi
中科院分区：
文献类型：
--
作者：
Kobayashi Yukiko;Tanizawa Midori;Ogata Midori;Aoi Wataru;Kuwahata Masashi
目的观察大强度运动减少摄食量对大鼠铁代谢的影响。方法36只4周龄雄性Wistar大鼠适应跑步后，随机分为6组：安静对照组、剧烈运动组、80%喂食+休息组、80%喂食+剧烈运动组、70%喂食+休息组、70%喂食+剧烈运动组。只有3个大强度运动组进行30min(30m/min)的急性跑步训练，每天1次，连续7d。结果在运动和限制饮食的情况下，大鼠没有发生贫血。运动组的血清铁水平、转铁蛋白饱和度、海普西丁-25和肝脏铁水平均低于各自的静息组。然而，70%节食组的这些值略高于80%节食组。血清促红细胞生成素水平随着食物摄入量的减少而降低，但70%喂养和大强度运动组的血清促红细胞生成素水平与安静对照组相似。限制摄食组的血清IL-6水平明显低于自由摄食组，运动对血清IL-6水平无明显影响。结论限制摄食量下的大强度运动可显著改变机体铁代谢，从而维持血细胞水平，这可能是由于饮食中铁耗竭、铁需求增加和排泄导致代谢铁利用增强所致。
ObjectivesThe purpose of this study was to observe changes in iron metabolism of rats due to high-intensity exercise during reduced food intake.MethodsThirty-six, 4-wk-old male Wistar rats were divided into six groups after being acclimated to running: rested control, intense exercise, 80% feeding and rested, 80% feeding and intense exercise, 70% feeding diet and rested, and 70% feeding and intense exercise groups. Only three intense exercise groups underwent acute running sessions for 30 min (30 m/min) once a day for 7 d.ResultsRats did not develop anemia with exercise and food intake restriction. Serum iron levels, transferrin saturation, hepcidin-25, and hepatic iron levels in the exercise groups were lower than those in the respective resting groups. However, these values in the 70% diet groups were slightly higher than those in the 80% diet groups. Serum erythropoietin levels decreased as food intake decreased, but the serum erythropoietin level in the 70% feeding and intense exercise group was similar to that in the rested control group. Serum interleukin-6 levels were significantly lower in the groups with restricted food intake than in the free-fed group, and exercise had no effect.ConclusionsHigh-intensity exercise under restricted food intake may significantly alter the iron metabolism to maintain blood cell levels due to the strong promotion of metabolic iron utilization in response to dietary iron depletion, increased iron demand, and excretion.