Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascular disease biomarkers in obese adolescents.
Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascular disease biomarkers in obese adolescents.
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DOI：
10.1111/pedi.12242
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发表时间：
2016-03
影响因子：
3.4
通讯作者：
Koren D
中科院分区：
文献类型：
--
作者：
Katz LE;Gralewski KA;Abrams P;Brar PC;Gallagher PR;Lipman TH;Brooks LJ;Koren D
胰岛素样生长因子（IGF）-I和IGF结合蛋白（IGFBP）-1与成人心血管疾病（CVD）风险和病理生理学有关，但在青年中的数据有限。该研究的目的是在肥胖儿童队列中检查IGF和IGFBP-1与传统和非传统CVD风险因素（包括炎症标志物和身体成分）之间的关系。一项横向研究。这项研究是在一所大学的儿童医院进行的。61名肥胖非糖尿病青少年。空腹IGF-I、IGFBP-1、脂蛋白谱、高敏C反应蛋白（hsCRP）和总脂联素以及胰岛素敏感性测量、血压（BP）和人体测量。IGFBP-1与男性的胰岛素敏感性指标、体重指数（BMI）和舒张压呈负相关。IGF-I与hsCRP呈负相关（r =-0.479，p < 0.0005），IGFBP-1与脂联素呈正相关（r = 0.545，p < 0.0005）。当控制BMI和胰岛素敏感性指数（SI）时，IGF-I/CRP和IGFBP-1/脂联素相关性仍然显著。IGF-I和IGFBP-1均与腰围（分别为r =-0.327和r =-0.275）和矢状腹径（分别为r =-0.333和r =-0.371）呈负相关，而IGFBP-1与男性的脂肪量（r =-0.347，p = 0.01）以及颈围和无脂肪量呈负相关。控制BMI z评分和SI，IGFBP-1与男性舒张压（r = 0.706，p = 0.001）和颈围（r =-0.548，p = 0.15）呈负相关。IGF-I和IGFBP-1与CVD风险标志物相关，并可能增加青年心脏代谢功能障碍的临床评估。
Insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 have been linked to cardiovascular disease (CVD) risk and pathophysiology in adults, but there are limited data in youth. The aim of the study was to examine the relationship between IGF and IGFBP-1 with traditional and non-traditional CVD risk factors including inflammatory markers and body composition in an obese pediatric cohort. A cross-sectional study. The study was carried out at a university children’s hospital. Sixty-one obese non-diabetic adolescents. Fasting IGF-I, IGFBP-1, lipoprotein profiles, high-sensitivity C-reactive protein (hsCRP), and total adiponectin as well as insulin sensitivity measures, blood pressure (BP), and anthropometrics. IGFBP-1 was negatively associated with insulin sensitivity measures, body mass index (BMI), and diastolic BP in males. IGF-I was negatively associated with hsCRP (r = −0.479, p < 0.0005), and IGFBP-1 was positively associated with adiponectin (r = 0.545, p < 0.0005). The IGF-I/CRP and IGFBP-1/adiponectin associations remained significant when controlling for both BMI and insulin sensitivity index (SI). Both IGF-I and IGFBP-1 were negatively associated with waist circumference (r = −0.327 and r = −0.275, respectively) and sagittal abdominal diameter (r = −0.333 and r = −0.371, respectively), while IGFBP-1 was negatively associated with fat mass (r = −0.347, p = 0.01) as well as neck circumference and fat-free mass in males. Controlling for BMI z-score and SI, IGFBP-1 remained negatively associated with diastolic blood pressure (r = 0.706, p = 0.001 and neck circumference (r = −0.548, p = 0.15) in males. IGF-I and IGFBP-1 associate with CVD risk markers and may add to clinical assessments of cardiometabolic dysfunction in youth.