The 1957 MRC report on leukaemia and aplastic anaemia in patients irradiated for ankylosing spondylitis
The 1957 MRC report on leukaemia and aplastic anaemia in patients irradiated for ankylosing spondylitis
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1957 年 MRC 关于因强直性脊柱炎接受放射治疗的患者出现白血病和再生障碍性贫血的报告
DOI：
10.1088/0952-4746/27/4b/r01
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发表时间：
2007
影响因子：
1.5
通讯作者：
Peter G. Smith
中科院分区：
文献类型：
--
作者：
Peter G. Smith
暴露于低剂量电离辐射的致癌效应的估计主要依赖于外推的影响，在两个人口暴露于相对较高的剂量-在日本原子弹爆炸的幸存者和患者在英国治疗的关节炎条件强直性脊柱炎的X射线。对14000多名放射性脊柱炎患者白血病风险的研究在20世纪50年代中期在极短的时间内完成。原始研究的完整报告很难获得，因为它没有发表在期刊上，而只是作为英国医学研究理事会的特别报告。为纪念该报告发表50周年，现将该报告全文转载于本期《日刊》。这篇随附的综述描述了研究的背景、主要发现和对记录了与X射线治疗相关的癌症和白血病风险的人群的进一步随访。这项研究的设计师是放射生物学家迈克尔·考特-布朗和流行病学家理查德·多尔。他们对脊椎炎患者白血病风险的富有成效的研究催生了终身合作，包括对辐射暴露致癌作用的进一步开创性研究，这些研究也在综述中进行了总结。
The estimation of the carcinogenic effects of exposure to low doses of ionizing radiation has depended primarily on extrapolation from effects seen in two populations exposed to relatively high doses—the survivors of the atomic bomb explosions in Japan and patients treated in the UK with x-rays for the arthritic condition ankylosing spondylitis. The study of the leukaemia risk in over 14000 irradiated spondylitis patients was completed in an astonishingly short period of time in the mid-1950s. The full report of the original study has been difficult to access because it was not published in a journal but only as a Special Report of the UK Medical Research Council. To mark 50 years since this publication this full report is reproduced in this issue of the Journal. This accompanying review describes the background to the study, the principal findings and the further follow-up of the population that documented the risks of cancers in addition to leukaemia associated with the x-ray treatment. The architects of the study were a radiobiologist, Michael Court-Brown, and an epidemiologist, Richard Doll. Their very productive study of the leukaemia risk among spondylitics spawned a lifelong collaboration including further seminal studies of the carcinogenic effects of radiation exposure, which are also summarised in the review.