Sentence processing strategies in healthy seniors with poor comprehension: An fMRI study
Sentence processing strategies in healthy seniors with poor comprehension: An fMRI study
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DOI：
10.1006/brln.2001.2581
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发表时间：
2002-03-01
影响因子：
2.5
通讯作者：
Gee, J
中科院分区：
文献类型：
--
作者：
Grossman, M;Cooke, A;Gee, J
我们使用fMRI检查了22名健康老年人的大脑招募模式，其中一半人对语法复杂的句子有选择性理解困难。我们发现，与句子理解能力良好的健康老年人相比，语言理解能力差的老年人的左后外侧颞叶[布罗德曼区（BA）22/21]和左下额叶（BA 44/6）皮层的招募显著减少，这些皮层区域分别与语言理解和言语工作记忆相关。学习成绩差的人在理解语法较简单的句子时，左前额叶（BA 9/46）、右背下额叶（BA 44/6）和左后扣带回（BA 31/23）皮层的激活程度更高。我们假设这些大脑区域支持一种替代的、非语法的策略来处理符号信息的复杂配置。此外，这些观察结果强调了左大脑外侧裂网络在具有良好理解力的受试者中语法指导的句子处理中的关键作用。(C)2002 Elsevier Science（美国）。
We used fMRI to examine patterns of brain recruitment in 22 healthy seniors, half of whom had selective comprehension difficulty for grammatically complex sentences. We found significantly reduced recruitment of left posterolateral temporal [Brodmann area (BA) 22/21] and left inferior frontal (BA 44/6) cortex in poor comprehenders compared to the healthy seniors with good sentence comprehension, cortical regions previously associated with language comprehension and verbal working memory, respectively. The poor comprehenders demonstrated increased activation of left prefrontal (BA 9/46), right dorsal inferior frontal (BA 44/6), and left posterior cingulate (BA 31/23) cortices for the grammatically simpler sentences that they understood. We hypothesize that these brain regions support an alternate, nongrammatical strategy for processing complex configurations of symbolic information. Moreover, these observations emphasize the crucial role of the left perisylvian network for grammatically guided sentence processing in subjects with good comprehension. (C) 2002 Elsevier Science (USA).