Copper-Catalyzed Selective ortho-C-H/N-H Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids

Copper-Catalyzed Selective ortho-C-H/N-H Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids
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铜催化苯甲酰胺与芳烃的选择性邻位 C-H/N-H 环化:菲啶酮生物碱的合成

DOI:
10.1021/acs.orglett.7b00442
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发表时间:
2017
期刊:
影响因子:
5.2
通讯作者:
Zhang Shu-Yu
Zhang Shu-Yu
中科院分区:
化学1区
文献类型:
--
作者:
Zhang Ting-Yu;Lin Jun-Bing;Li Quan-Zhe;Kang Jun-Chen;Pan Jin-Long;Hou Si-Hua;Chen Chao;Zhang Shu-Yu

文献摘要

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An efficient and convenient copper-catalyzed method has been developed to achieve directortho-C–H/N-H annulation to synthesize phenanthridinones with arynes. This method highlights an emerging strategy to transform inert C–H bonds into versatile functional groups in organic synthesis and provides a new way to synthesize phenanthridinone alkaloids efficiently.