Survival of cancer in patients with rheumatoid arthritis: a follow-up study in Sweden of patients hospitalized with rheumatoid arthritis 1 year before diagnosis of cancer
Survival of cancer in patients with rheumatoid arthritis: a follow-up study in Sweden of patients hospitalized with rheumatoid arthritis 1 year before diagnosis of cancer
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DOI：
10.1093/rheumatology/ker143
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发表时间：
2011-08-01
期刊：
影响因子：
5.5
通讯作者：
Sundquist, Jan
中科院分区：
文献类型：
--
作者：
Ji, Jianguang;Liu, Xiangdong;Sundquist, Jan
方法.通过与癌症登记处的联系，从瑞典医院出院登记处确定RA患者。从癌症诊断之日起至2006年开始对患者进行随访。计算RA患者与非RA患者的风险比（HR）。在数据库中共确定了1411163例癌症患者，其中6309例既往因RA住院。与所有无RA的癌症患者相比，RA患者的预后更差，病因特异性生存率和总生存率的HR分别为1.29和1.31。对于特定的癌症部位，皮肤癌、乳腺癌和非霍奇金淋巴瘤的生存率最低。年龄分层并没有改变结果。与非RA患者相比，既往因RA住院的癌症患者的所有和许多部位特异性癌症的预后较差，与诊断时的年龄和肿瘤分期无关。提高类风湿性关节炎癌症患者的生存率可能需要多学科的方法来适应合并症。
Methods. RA patients were identified from the Swedish Hospital Discharge Register by linkage to the Cancer Registry. Follow-up of patients was started from the date of diagnosis of cancer through year 2006. Hazard ratios (HRs) were calculated in cancer patients with RA compared with subjects without RA.Results. A total of 1 411 163 cancer patients were identified in the database, of whom 6309 had a previous hospitalization for RA. Compared with all cancer patients without RA, patients with RA had a worse prognosis, with an HR of 1.29 and 1.31 for cause-specific and overall survival, respectively. For specific cancer sites, skin and breast cancers and non-Hodgkin's lymphoma showed worst survival. Age stratification did not change the results.Conclusion. Cancer patients with a previous hospitalization for RA had a worse prognosis for all and many site-specific cancers compared with patients without RA, independent of age at diagnosis and tumour staging. Improvement of survival for cancer patients with RA may require a multidisciplinary approach to accommodate the comorbidity.