Molecules in focus: Indoleamine 2,3-dioxygenase
Molecules in focus: Indoleamine 2,3-dioxygenase
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DOI：
10.1016/j.biocel.2007.01.004
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Thomas, Shane R.
中科院分区：
文献类型：
--
作者：
King, Nicholas J. C.;Thomas, Shane R.
吲哚胺2，3-双加氧酶（IDO）是一种血红素酶，其沿着犬尿氨酸途径引发最不丰富的必需氨基酸L-色氨酸的氧化降解。L-色氨酸的局部细胞消耗可能使宿主能够抑制体内各种感染性病原体的生长。然而，在过去的十年中，越来越明显的是，IDO也是一种重要的免疫控制酶。因此，表达IDO的细胞似乎矛盾地能够抑制局部T细胞应答以促进在医学重要性的各种生理和病理生理条件下的免疫耐受，所述生理和病理生理条件包括感染性疾病、胎儿排斥、器官移植、神经病理学、炎性和自身免疫病症以及癌症。在这篇综述中，我们简要概述了IDO的生化特性，其已知的和假设的功能，以及在健康和疾病中抑制或诱导IDO和/或其下游catalysts的医学意义。(C)2007爱思唯尔有限公司保留所有权利。
Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, L-tryptophan, along the kynurenine pathway. The local cellular depletion Of L-tryptophan that results may enable the host to inhibit the growth of various infectious pathogens in vivo. However, over the past decade, it has become increasingly apparent that IDO also represents an important immune control enzyme. Thus, cells expressing IDO, seemingly paradoxically, are capable of suppressing local T cell responses to promote immune tolerance under various physiological and pathophysiological conditions of medical importance, including infectious diseases, foetal rejection, organ transplantation, neuropathology, inflammatory and auto-immune disorders and cancer. In this review, we briefly outline the biochemical properties of IDO, its known and hypothetical functions and the medical implications for inhibition or induction of IDO and/or its downstream catabolites in health and disease. (C) 2007 Elsevier Ltd. All rights reserved.