A preliminary metabolomic analysis of older adults with and without depression
A preliminary metabolomic analysis of older adults with and without depression
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DOI：
10.1002/gps.1690
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发表时间：
2007-05-01
影响因子：
4
通讯作者：
Steffens, David C.
中科院分区：
文献类型：
--
作者：
Paige, Lisa A.;Mitchell, Matthew W.;Steffens, David C.
背景代谢组学是一门新兴的生物化学科学，能够对参与代谢和信号通路的小分子进行检测和定量。疾病及其治疗的代谢特征可以提供有价值的生物标志物和疾病机制的见解。在这项试点研究中，我们评估代谢组学在老年抑郁症patients.Methods的研究潜力，我们进行了9个抑郁症，11个缓解，和10个从不抑郁的老年人的血浆代谢组学分析。大约800代谢物进行了分析，与三个groups.Results之间的比较，在目前抑郁症患者与对照组相比，包括几种脂肪酸，甘油和γ-氨基丁酸（GABA）的代谢物被改变。比较缓解和目前抑郁症患者的浓度分析显示，代谢物改变模式与对照组和目前抑郁症分析相似。与抑郁症患者相比，缓解期患者的一个差异是酮3-羟基丁酸浓度升高。结论这些观察结果表明，抑郁状态可能与脂质和神经递质代谢的改变有关，抗抑郁药治疗可以调节疾病中的一些异常途径，使缓解期患者的代谢谱与而不是抑郁症患者。这些结果需要在更大的纵向队列中进行检查和验证。版权所有（c）2006约翰威利父子有限公司。
Background Metabolomics, the global science of biochemistry, is an emerging field that enables detection and quantification of small molecules involved in metabolic and signaling pathways. Metabolic signatures for disease and its treatment could provide valuable biomarkers and insights about disease mechanisms. In this pilot study, we evaluate the potential of metabolomics in the study of older depressed patients.Methods We performed a metabolomic analysis of blood plasma from nine depressed, 11 remitted, and ten never-depressed older adults. Approximately 800 metabolites were analyzed, with comparisons made among the three groups.Results Metabolites that were altered in currently depressed patients when compared with controls included several fatty acids, glycerol and gamma-aminobutyric acid (GABA). Analyses comparing concentrations in remitted and currently depressed patients revealed a pattern of metabolite alterations similar to the control vs currently depressed analyses. One difference observed in the remitted patients relative to the depressed patients was elevation of the concentration of the ketone 3-hydroxybutanoic acid.Conclusion These observations suggest that the depressed state may be associated with alterations in the metabolism of lipids and neurotransmitters, and that treatment with antidepressants adjusts some of the aberrant pathways in disease so that the patients in remission have a metabolic profile more similar to controls than to the depressed population. These results will need to be examined and validated in larger longitudinal cohorts. Copyright (c) 2006 John Wiley & Sons, Ltd.