Using Evaporation-Induced Self-Assembly for the Direct Drug Templating of Therapeutic Vectors with High Loading Fractions, Tunable Drug Release, and Controlled Degradation
Using Evaporation-Induced Self-Assembly for the Direct Drug Templating of Therapeutic Vectors with High Loading Fractions, Tunable Drug Release, and Controlled Degradation
复制标题
DOI：
10.1021/cm401807m
复制
发表时间：
2013-12-10
影响因子：
8.6
通讯作者：
Sanchez, Clement
中科院分区：
文献类型：
--
作者：
Fontecave, Thomas;Boissiere, Cedric;Sanchez, Clement
提出了一种新的设计非聚集二氧化硅介观结构治疗载体的一步法。蒸发诱导的自组装与两亲性药物组合用于制备已经加载的I类和II类杂化材料，其含有50至60重量%（高达75体积%）的三种药物（葡糖基-白藜芦醇、硬脂酰胆碱、槐糖脂）。良好的介观结构能够促进PBS介质中药物释放的界面控制。释放机制和基质溶解的调查进行了通过原位椭圆偏振和NMR。事实证明，调整药物释放速率必须同时考虑药物/基质相互作用的性质、药物/基质界面的化学组成以及介观结构质量参数，同时保持二氧化硅的溶解速率在合理的水平以限制其毒性。这也证明了非煅烧的原样制得的基于二氧化硅的I类杂化材料可以有效地用于将药物释放动力学从1小时调整到天规模。
A novel one-step approach for designing nonaggregated silica-based mesostructured therapeutic vectors is presented. Evaporation-induced self-assembly was used in combination with amphiphilic drugs for preparing already loaded class I and class II hybrid materials containing from 50 to 60 wt % (up to 75 vol %) of three drugs (glucosyl-resveratrol, stearoyl choline, sophorolipid). A good mesostructuration was able to promote an interfacial control of the drug release in PBS medium. The investigation of both release mechanisms and matrix dissolution was conducted via in situ ellipsometry and NMR. It proved that the nature of the drug/matrix interaction, the chemical composition of the drug/matrix interface, and the mesostructuration quality parameters must be taken into account at the same time for tuning the drug release rate, while maintaining the dissolution rate of silica at a reasonable level for limiting its toxicity. It proved also that noncalcined as-made silica-based class I hybrid materials can be efficiently used for tuning drug release kinetics from 1 h to day scale.