Maturation of Luteinizing Hormone (Gonadotropin-Releasing Hormone) Secretion across Puberty: Evidence for Altered Regulation in Obese Peripubertal Girls
Maturation of Luteinizing Hormone (Gonadotropin-Releasing Hormone) Secretion across Puberty: Evidence for Altered Regulation in Obese Peripubertal Girls
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DOI：
10.1210/jc.2008-1252
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发表时间：
2009-01-01
影响因子：
5.8
通讯作者：
Marshall, John C.
中科院分区：
文献类型：
--
作者：
McCartney, Christopher R.;Prendergast, Kathleen A.;Marshall, John C.
背景：女孩青春期肥胖（年龄体重指数>= 95%）与高雄激素血症有关。LH可能有助于这种关系，但是肥胖女孩的夜间LH分泌特征不佳。目的：本研究的目的是评估整个青春期成熟的肥胖女孩的LH脉冲特征。设计：我们进行了横断面分析。设置：本研究在一般临床研究中心进行。参与者：8名非肥胖和5名肥胖的坦纳1-2女孩参与了研究，32名非肥胖和12名肥胖的坦纳3-5女孩参与了研究。主要结果测量：在3个4小时的时间段内测量LH脉冲频率、幅度和平均LH（第1组，1900-2300时;第2组，2300-0300时;和第3组，0300-0700时）。坦纳1-2期非肥胖女孩表现出夜间LH频率（P < 0.01，区组1 vs. 2）和平均LH（P < 0.05，区组1 vs. 2和3）增加。肥胖的坦纳1-2女孩有较低的12小时LH频率和LH幅度（P < 0.05），没有LH脉冲参数的过夜变化。与正常人相比，坦纳3-5岁肥胖女孩LH频率升高（所有区组P < 0.01），而LH幅度降低（所有区组P < 0.05）。非肥胖坦纳3 -5岁女孩的LH振幅夜间增加（P < 0.0001），而肥胖坦纳3-5岁女孩的LH振幅夜间增加不明显。在青春期后期的女孩中，肥胖与LH幅度降低有关，但LH频率升高;后者可能反映了高雄激素血症的影响。（J Clin Endocrinol Metab 94：56-66，2009）
Context: Peripubertal obesity (body mass index-for-age >= 95%) in girls is associated with hyperandrogenemia. LH likely contributes to this relationship, but overnight LH secretion in obese girls is poorly characterized.Objective: The aim of the study was to evaluate LH pulse characteristics in obese girls throughout pubertal maturation.Design: We conducted a cross-sectional analysis.Setting: The study was performed in a general clinical research center.Participants: Eight nonobese and five obese Tanner 1-2 girls participated, as well as 32 nonobese and 12 obese Tanner 3-5 girls.Intervention: Blood samples were collected every 10 min overnight (from 1900 to 0700 h).Main Outcome Measures: LH pulse frequency, amplitude, and mean LH were measured in three 4-h time blocks (block 1, 1900-2300 h; block 2, 2300-0300 h; and block 3, 0300-0700 h).Results: Tanner stage 1-2 nonobese girls demonstrated nocturnal increases of LH frequency (P < 0.01, block 1 vs. 2) and mean LH (P < 0.05, block 1 vs. 2 and 3). Obese Tanner 1-2 girls had lower 12-h LH frequency and LH amplitude (P < 0.05 for both), with no overnight changes of LH pulse parameters. Compared to normal, LH frequency was elevated in Tanner 3-5 obese girls (P < 0.01 in all blocks), whereas LH amplitude was low (P < 0.05 in all blocks). Overnight increases of LH amplitude were observed in nonobese Tanner 3-5 girls (P < 0.0001), but not in obese Tanner 3-5 girls.Conclusions: Obesity in prepubertal and early pubertal girls is associated with reduced LH secretion and reduced nocturnal changes of LH. In later pubertal girls, obesity is linked with reduced LH amplitude, but elevated LH frequency; the latter may reflect effects of hyperandrogenemia. (J Clin Endocrinol Metab 94: 56-66, 2009)