Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass.
Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass.
复制标题
从儿童期到成年早期静息心率轨迹的快速下降与心脏质量的增加存在着矛盾的关系。
DOI：
10.1080/00015385.2020.1871262
复制
发表时间：
2021
影响因子：
1.6
通讯作者：
Kapuku,Gaston
中科院分区：
文献类型：
--
作者：
Hao,Guang;Halbert,James;Su,Shayong;Bagi,Zsolt;Robinson,Vincent;Thayer,Julian;Harshfield,Gregory;Kapuku,Gaston
背景从童年到青年时期的静息心率（RHR）轨迹模式及其临床意义，我们所知甚少。我们的目的是确定RHR从童年到青年期的轨迹，并确定它们与左心室质量（LVM）指数的关系。方法在21年的时间里，对759名从童年到青年的参与者进行了多达15次的srhr测量。546名参与者采用超声心动图测量LVM，并与体表面积归一化得到LVM指数。结果采用潜类模型，将RHR从儿童期到青年期分为高下降组（HDG）、中下降组（MDG）和低下降组（LDG）三个轨迹组。我们发现RHR轨迹是LVM指数的显著预测因子，RHR下降越快，总外周阻力越高（趋势p <0.001）， LVM指数越高（趋势p <0.001）。与LDG组相比，HDG组个体的LVM指数更高（β= 6.08,p< 0.001）。此外，种族与RHR轨迹在LVM指数上的交互作用显著（p< 0.05）。结论：我们的研究结果表明，儿童期至青年期的RHR轨迹与心脏质量之间存在关联，这表明监测RHR可能有助于识别心血管高危亚群。
BackgroundLittle is known about the varied resting heart rate (RHR) trajectory patterns from childhood to young adulthood and their clinical significance. We aim to identify RHR trajectories from childhood to young adulthood, and to determine their relationship with left ventricular mass (LVM) index.MethodsRHR was measured up to 15 times over a 21-year period in 759 participants from childhood to young adulthood. LVM was measured using echocardiography and was normalised to body surface area to obtain LVM index in 546 participants.ResultsUsing latent class models, three trajectory groups in RHR from childhood to young adulthood were identified, including high-decreasing group (HDG), moderate-decreasing group (MDG), and low-decreasing group (LDG). We found that trajectory of RHR was a significant predictor of LVM index with faster decrease of RHR associated with higher levels of total peripheral resistance (Pfor trend <0.001) and LVM index (Pfor trend <0.001). Compared to the LDG, individuals in the HDG showed higher LVM index (β= 6.08,p< 0.001). In addition, the interactions between race and RHR trajectories for LVM index was significant (p< 0.05).ConclusionOur findings show an association between RHR trajectories from childhood to young adulthood with cardiac mass, suggesting that monitoring RHR may help identify subpopulation at high cardiovascular risk.