Rostral locus coeruleus integrity is associated with better memory performance in older adults
Rostral locus coeruleus integrity is associated with better memory performance in older adults
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DOI：
10.1038/s41562-019-0715-2
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发表时间：
2019-11-01
影响因子：
29.9
通讯作者：
Werkle-Bergner, Markus
中科院分区：
文献类型：
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作者：
Dahl, Martin J.;Mather, Mara;Werkle-Bergner, Markus
几十年来，对人类认知老化中记忆衰退的研究一直集中在新皮层区域、海马和多巴胺能神经调节上。最近的研究结果表明，蓝斑（LC）和去甲肾上腺素能神经调节也可能发挥重要作用，在塑造记忆发展在以后的生活。然而，量化LC完整性的技术挑战阻碍了人类LC-认知关联的研究。使用高分辨率，神经黑色素敏感的磁共振成像，我们发现学习和记忆的个体差异与年轻人（n = 66）和老年人（n = 228）在各种记忆任务中的LC完整性呈正相关。此外，我们观察到功能相关的年龄差异仅限于喙LC。更“年轻”的吻侧LC的老年人也表现出更高的记忆力。这些发现将LC完整性的非侵入性体内指数与衰老中的记忆联系起来，并突出了LC去甲肾上腺素系统在认知下降中的作用。
For decades, research into memory decline in human cognitive ageing has focused on neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation may also play an important role in shaping memory development in later life. However, technical challenges in quantification of LC integrity have hindered the study of LC-cognition associations in humans. Using high-resolution, neuromelanin-sensitive magnetic resonance imaging, we found that individual differences in learning and memory were positively associated with LC integrity across a variety of memory tasks in both younger (n = 66) and older adults (n = 228). Moreover, we observed functionally relevant age differences confined to rostral LC. Older adults with a more 'youth-like' rostral LC also showed higher memory performance. These findings link non-invasive, in vivo indices of LC integrity to memory in ageing and highlight the role of the LC norepinephrine system in the decline of cognition.