Familial Clustering of Mitral Valve Prolapse in the Community
Familial Clustering of Mitral Valve Prolapse in the Community
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DOI：
10.1161/circulationaha.114.012594
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发表时间：
2015-01-20
期刊：
影响因子：
37.8
通讯作者：
Vasan, Ramachandran S.
中科院分区：
文献类型：
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作者：
Delling, Francesca N.;Rong, Jian;Vasan, Ramachandran S.
背景-二尖瓣脱垂 (MVP) 遗传的知识基于谱系观察和 M 型超声心动图。使用当前更具体的超声心动图标准，社区中未经选择的个体中 MVP 的家族聚集程度尚不清楚。此外，非诊断性 MVP 形态（NDM；首次在大型谱系中描述）的重要性尚未在普通人群中进行研究。我们假设父母 MVP 和 NDM 会增加后代 MVP 的风险。方法和结果研究参与者是 3679 名第 3 代个体，他们在后代或新后代配偶队列中拥有可用的父母数据。 MVP 和 NDM 的区别在于小叶位移 >2 与
Background-Knowledge of mitral valve prolapse (MVP) inheritance is based on pedigree observation and M-mode echocardiography. The extent of familial clustering of MVP among unselected individuals in the community using current, more specific echocardiographic criteria is unknown. In addition, the importance of nondiagnostic MVP morphologies (NDMs; first described in large pedigrees) has not been investigated in the general population. We hypothesized that parental MVP and NDMs increase the risk of offspring MVP.Methods and Results-Study participants were 3679 Generation 3 individuals with available parental data in the Offspring or the New Offspring Spouse cohorts. MVP and NDMs were distinguished by leaflet displacement >2 versus