Peripartum maternal transmission of extended-spectrum β-lactamase organism to newborn infants
Peripartum maternal transmission of extended-spectrum β-lactamase organism to newborn infants
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DOI：
10.1016/j.diagmicrobio.2016.11.004
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发表时间：
2017-02-01
影响因子：
2.9
通讯作者：
Kushnir, Amir
中科院分区：
文献类型：
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作者：
Peretz, Avi;Skuratovsky, Alina;Kushnir, Amir
本研究的目的是确定是否超广谱β-内酰胺酶（ESBL）的传播途径，住院新生儿是从他们的母亲在分娩。新生儿重症监护室（NICU）住院新生儿在出生后第1天和第4天通过粪便培养进行ESBL采样。对ESBL阳性新生儿的母亲进行采样，以进行可能的相关性检测。细菌分离株进行分子鉴定和抗生素敏感性试验进行。ESBL阳性14例（62%），大肠埃希菌阳性10例（4.4%），肺炎克雷伯菌阳性4例（1.7%）。在14例阳性新生儿母亲中，13例（92.8%）检出ESBL阳性，1例新生儿母亲检出E.发现弹簧圈支架呈ESBL阴性。鉴定了编码ESBL抗性的基因。药敏试验和耐药性测定。本研究表明，新生儿重症监护病房（NICU）中ESBL菌携带者可能是分娩过程中母婴传播的结果。(C)2016 Elsevier Inc. All rights reserved.
The aim of this study was to determine whether the route of extended-spectrum beta-lactamase (ESBL) transmission to hospitalized newborns was from their mothers during delivery. Neonatal intensive care unit (NICU) hospitalized newborns were sampled for ESBL presence by stool cultures on the first and fourth days of life. Mothers of ESBL-positive newborns were sampled for possible correlation detection. Bacteria isolates were molecularly identified and susceptibility tests for antibiotic agents were performed. Of the 225 newborns, 14 (62%) were ESBL positive, 10 (4.4%) were Escherichia coli positive, and 4 (1.7%) were Klebsiella pneumoniae positive. Among the 14 mothers of positive newborns, 13 (92.8%) were found ESBL positive and one mother of a newborn with E. coil carriage was found ESBL negative. Genes encoding for ESBL resistance were identified. Antibiotic sensitivity and resistance were tested. This study demonstrated that ESBL bacteria carrier neonates hospitalized in NICU may be a result of transmission from mother to baby during delivery. (C) 2016 Elsevier Inc. All rights reserved.