Documentation of impaired coronary blood flow by TIMI frame count method in patients with atrial fibrillation
Documentation of impaired coronary blood flow by TIMI frame count method in patients with atrial fibrillation
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DOI：
10.1016/j.ijcard.2012.03.118
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发表时间：
2013-08-20
影响因子：
3.5
通讯作者：
Gao, Xiuren
中科院分区：
文献类型：
--
作者：
Luo, Chufan;Wu, Xing;Gao, Xiuren
背景：心房颤动(房颤)与冠脉流量受损和心肌灌注减少有关。在这项研究中，我们旨在通过心肌梗死溶栓(TIMI)和帧计数(TFC)的方法来评估无梗阻性冠状动脉疾病(CAD)的房颤患者的冠状动脉血流量。方法：这项前瞻性研究最初纳入了166例房颤患者和332名年龄和性别匹配的对照组。结果：房颤组三支主要冠状动脉的TFC及平均TFC显著高于对照组(34.1+/-10.4vs.25.0+/-10.4，31.8+/-9.7vs.23.7+/-9.1，P<0.05)。平均TFC分别为32.8+/-9.2和24.3+/-8.9。
Background: Atrial fibrillation (AF) is associated with impaired coronary flow and diminished myocardial perfusion. In the present study we aimed to evaluate coronary blood flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) in patients with AF in the absence of obstructive coronary artery disease (CAD).Methods: This prospective study initially enrolled 166 patients with AF and 332 age-and gender-matched control subjects without AF. After diagnostic coronary angiography, TFC was assessed in the participants without obstructive CAD, with 146 in the AF group and 150 in the control group.Results: The TFC for three major coronary arteries and the mean TFC were found to be significantly higher in AF patients compared to control subjects (34.1+/-10.4 vs. 25.0+/-10.4, 31.8+/-9.7 vs. 23.7+/-9.1, and 32.3+/-9.5 vs. 24.1+/-8.4 for each artery and 32.8+/-9.2 vs. 24.3+/-8.9 for mean TFC, p