A macrocycle directed total synthesis of di- O -methylendiandrin A
A macrocycle directed total synthesis of di- O -methylendiandrin A
复制标题
二-O-亚甲基二苯甲酮大环定向全合成
DOI：
10.1039/d0cc03302b
复制
发表时间：
2020
影响因子：
4.9
通讯作者：
Merner, Bradley L.
中科院分区：
文献类型：
--
作者：
Barnes, Timothy H.;Johnson, Kara F.;Gorden, John D.;Merner, Bradley L.
利用大环1，4-二酮的非对映选择性、邻位烷基化和跨环McMurry反应作为建立相对立体化学和提供天然产物的应变四元环的关键转化，实现了基于木脂素的环丁烷二-O-亚甲基二andrin A的全合成。
The total synthesis of the lignan-based cyclobutane di-O-methylendiandrin A has been achieved using diastereoselective, vicinal alkylation and transannular McMurry reactions of a macrocyclic 1,4-diketone as key transformations for establishing relative stereochemistry and furnishing the strained 4-membered ring of the natural product.