Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia
Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia
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DOI：
10.1021/np060172v
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发表时间：
2006-11-27
影响因子：
5.1
通讯作者：
Proksch, Peter
中科院分区：
文献类型：
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作者：
Ashour, Mohamed;Edrada, RuAngelie;Proksch, Peter
从印度囊舌类软体动物Elysia grandifolia中分离得到两个新的环状缩肽衍生物kahalalides R（1）和S（2），以及两个已知的同类物kahalalides F（3）和D（4）。新化合物的结构是基于NMR光谱（H-1，C-13，COSY，HMBC）和质谱（FABMS，ESIMS，MALDI-TOF/PSD）数据明确确定的，其中还包括Marvel氨基酸分析。发现新衍生物kahalalide R对MCF 7人乳腺癌细胞系的细胞毒性与潜在候选药物kahalide F相当或甚至更高。
Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalides F (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (H-1, C-13, COSY, HMBC) and mass spectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahalalide F toward the MCF7 human mammary carcinoma cell line.